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Huntingtin 抗体 (AA 1844-2131)

Name: Huntingtin 抗体 (AA 1844-2131)
SKU: ABIN119306
Availability: OutOfStock

HTT 适用: 人, 小鼠, 兔 WB, IP, IHC (fro) 宿主: 小鼠 Monoclonal HDB4E10 unconjugated

Total protein extract of normal human cerebral cortex separated as a strip on a 3-

1 image

产品编号 ABIN119306

发货至: 中国

Datasheet as PDF

抗原 See all Huntingtin (HTT) 抗体

Huntingtin (HTT)
抗原表位
15

7

4

4

4

4

3

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
AA 1844-2131
适用
64

46

37

5

3

2

2

1

1

1

1

1

1

1

1

1

1
人, 小鼠, 兔
宿主
61

21

2
小鼠
Compatible Secondaries
克隆类型
54

29
单克隆
标记
56

3

3

3

3

3

3

3

1

1

1

1

1

1

1
This Huntingtin antibody is un-conjugated
应用范围
41

33

26

14

14

13

12

8

7

4

4

2

1

1
Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

特异性

This antibody reacts with an epitope corresponding to the HDB region (amino acids 1844-2131) of the Huntingtin protein. The combined use of Clone HDB4E10 (Cat.-No SM1661), HDC8A4 (Cat.-No SM1662) and HDA3E10 (Cat.-No SM1660) demonstrate that huntingtin is enriched in neuronal cells in the brain.

纯化方法

Purified

免疫原

Recombinant protein corresponding to amino acids 1844 - 2131 of huntingtin

克隆位点

HDB4E10

亚型

IgG1

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anti-Huntingtin (HTT) (AA 81-191) antibody
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anti-Huntingtin (HTT) (AA 2703-2911) antibody
HTT 适用: 人, 兔 WB, IHC, IP, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal unconjugated

应用备注

Western Blot: Clone HDB4E10 detects a 350KD band on western blots but also detects smaller degradation products of huntingtin. Immunoprecipitation. Immunohistochemistry on frozen sections. Recommended positive control tissue: Brain.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
浓度

1.0 mg/mL

缓冲液

PBS, 0.09 % Sodium Azide

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
抗原

Huntingtin (HTT)

别名

Huntingtin (HTT 产品)

别名

HTT antibody, hd antibody, ZHD antibody, CG9995 antibody, Dmel\\CG9995 antibody, HD antibody, Hsap\\HD antibody, Htt antibody, dHtt antibody, dhtt antibody, SLC6A4 antibody, huntington antibody, it15 antibody, htt antibody, IT15 antibody, AI256365 antibody, C430023I11Rik antibody, Hd antibody, Hdh antibody, huntingtin antibody, HTT antibody, htt antibody, LOC373520 antibody, Htt antibody

背景

Huntington's disease (HD) is a neurodegenerative disorder caused by an expanding polyglutamine repeat in the huntingtin gene. HD is a mid-life onset autosomal dominant neurodegeneative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years. The HD gene product is widely expressed in human tissues, with the highest level of expression in the brain. The huntingtin gene product is expressed at similar levels in patients and controls, which suggests that the expansion of the polyglutamine repeat induces a toxic gain of function perhaps through interactions with other cellular proteins. Using yeast two-hybrid system, HAP1 (huntingtin associated protein 1) has been identified, that associates with huntingtin protein. The In vitro data suggest that the association between HAP1 and huntingtin is enhanced by increasing length of glutamine repeat.Synonyms: HD, HTT, Huntington Disease Protein, IT15

基因ID

3064

NCBI登录号

NP_002102

UniProt

P42858

途径

PI3K-Akt Signaling, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport