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Myeloperoxidase 抗体 (PE)

MPO 适用: 人 FACS 宿主: 小鼠 Monoclonal 2C7 PE
产品编号 ABIN119049
发货至: 中国
  • 抗原 See all Myeloperoxidase (MPO) 抗体
    Myeloperoxidase (MPO)
    适用
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    宿主
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    小鼠
    克隆类型
    • 121
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    单克隆
    标记
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    This Myeloperoxidase antibody is conjugated to PE
    应用范围
    • 124
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    Flow Cytometry (FACS)
    无交叉反应
    大鼠
    交叉反应 (详细)
    Species reactivity (tested):Human.
    纯化方法
    Affinity Chromatography on Protein G
    免疫原
    Human Myeloperoxiase Remarks: Spleen cells from immunised mice were fused with cells of the mouse X63 AG8-653 myeloma cell line.
    克隆位点
    2C7
    亚型
    IgG1
    Top Product
    Discover our top product MPO Primary Antibody
  • 应用备注
    Flow cytometry: Membrane permeabilisation is required for this application.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 溶解方式
    Restore with 1 mL distilled water
    浓度
    1.0 mg/mL
    缓冲液
    PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative, 1 % BSA and 5 % sucrose as stabilizer
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    This product is photosensitive and should be protected from light
    储存条件
    4 °C
    储存方法
    Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
  • Lau, Mollnau, Eiserich, Freeman, Daiber, Gehling, Brümmer, Rudolph, Münzel, Heitzer, Meinertz, Baldus: "Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 2, pp. 431-6, (2005) (PubMed).

  • 抗原
    Myeloperoxidase (MPO)
    别名
    Myeloperoxidase (MPO 产品)
    别名
    mKIAA4033 antibody, MPO antibody, LOC100335032 antibody, POX2' antibody, XPOX2' antibody, mpo antibody, mpo-A antibody, pmr-1 antibody, pmr1 antibody, pox2 antibody, xpox2 antibody, myeloperoxidase antibody, myeloperoxidase L homeolog antibody, MPO antibody, Mpo antibody, LOC100335032 antibody, mpo.L antibody
    背景
    MPO is an important component of azurophilic granules in neutrophils. Myeloperoxidase is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. Native Myeloperoxidase is represented as a covalently bound tetrameric complex of two glycosylated alpha chains (MW 59 - 64 kDa) and two unglycosylated beta chains (MW 14 kDa) with total MW 150 kDa and theoretical pI 9.2. Traditionally Myeloperoxidase was considered as a main target of anti-neutrophil cytoplasm antibodies (ANCA), the serological markers for certain systemic vasculities e.g. periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic granulomatosis (Churg-Strauss syndrome). Low to moderate anti-Myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Recently it was shown that Myeloperoxidase participates in the initiation and progression of cardiovascular disease. It possesses potent proinflammatory properties and may contribute directly to tissue injury. Now Myeloperoxidase is under consideration as one of the most promising cardiac markers.Synonyms: MPO
    基因ID
    9606
    UniProt
    P05164
    途径
    Chromatin Binding
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