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SNAP25 抗体

SNAP25 适用: 人, 大鼠, Pig, Hamster WB, IHC (p), EIA 宿主: 小鼠 Monoclonal SP12 unconjugated
产品编号 ABIN119027
发货至: 中国
  • 抗原 See all SNAP25 抗体
    SNAP25 (Synaptosomal-Associated Protein, 25kDa (SNAP25))
    适用
    • 92
    • 62
    • 61
    • 9
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    • 4
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    人, 大鼠, Pig, Hamster
    宿主
    • 95
    • 19
    • 4
    • 4
    • 1
    小鼠
    克隆类型
    • 94
    • 26
    • 1
    单克隆
    标记
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    This SNAP25 antibody is un-conjugated
    应用范围
    • 88
    • 47
    • 27
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    • 16
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    • 9
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    特异性
    This antibody appears to recognize the pre-synaptic protein SNAP-25, an antigen of 26-27 kDa Molecular Weight. It will recognise SNAP-25 fusion protein from COS cells, but not the fusion protein from bacterial systems. Research studies have used this antibody to study the distribution of synaptic changes in the hippocampus of patients with medically refractory temporal lobe epilepsy. (1,3,8)
    纯化方法
    Affinity Chromatography on Protein A.
    免疫原
    Crude Human synaptic immunoprecipitate.
    克隆位点
    SP12
    亚型
    IgG1
    Top Product
    Discover our top product SNAP25 Primary Antibody
  • 应用备注
    Western Blot: 1/5000-1/10000. ELISA. Immunohistochemistry on Paraffin Sections: 1/2000-1/5000, This product does not require protein digestion pre-treatment of paraffin sections, This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections. Recommended positive control tissue: Brain.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS, pH 7.2 containing 0.09 % Sodium Azide as preservative.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    SNAP25 (Synaptosomal-Associated Protein, 25kDa (SNAP25))
    别名
    SNAP25 (SNAP25 产品)
    别名
    RIC-4 antibody, RIC4 antibody, SEC9 antibody, SNAP antibody, SNAP-25 antibody, bA416N4.2 antibody, dJ1068F16.2 antibody, SNAP-25B antibody, SNAP-25a antibody, ric-4 antibody, ric4 antibody, sec9 antibody, snap-25 antibody, Bdr antibody, sp antibody, fj55h11 antibody, snap25 antibody, wu:fj55h11 antibody, Snap antibody, snap25.2 antibody, wu:fj33h05 antibody, synaptosome associated protein 25 antibody, synaptosome associated protein 25kDa S homeolog antibody, synaptosomal-associated protein, 25kDa antibody, synaptosomal-associated protein 25 antibody, synaptosome associated protein 25kDa antibody, synaptosome associated protein 25kDa L homeolog antibody, zgc:101731 antibody, synaptosomal-associated protein, 25b antibody, SNAP25 antibody, Snap25 antibody, snap25.S antibody, snap25 antibody, BACOIKO003_07 antibody, Tsp_10811 antibody, snap25.L antibody, zgc:101731 antibody, snap25b antibody
    背景
    SNAP25 is a soluble protein of 25 kDa which plays a key role in vesicle membrane fusion events with the plasma membrane. This protein was originally discovered to be enriched in subsets of neurons in the brain and displays a presynaptic pattern of expression. The membrane proteins SNAP25, synaptobrevin, and syntaxin form the core of a ubiquitous membrane fusion machine that interacts with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. Functional interactions have been demonstrated to exist between SNAP-25, syntaxin, and the synaptic protein interaction site on voltage-sensitive L- and N-type calcium channels. SNAP-25 has been shown to be required for synaptic vesicle fusion with the plasma membrane during release of nerve growth factor (NGF). Regulated exocytosis of cortical granule secretion in fertilized eggs and membrane fusion events in neurons and endocrine cells is mediated by SNAP-25 in a calcium-dependent mechanism. SNAP25 protein levels have been shown to be elevated in prolactinoma and growth hormone (GH)/prolactin (PRL) tumor cells while reduced SNAP-25 protein expression has been observed between schizophrenic and normal hippocampal cells. Altered patterns of SNAP-25 expression have also been observed in the inferior temporal cortex and prefrontal association cortex between normal brains and brains from individuals affected with schizophrenia. SNAP25 accumulation due to cytoskeletal dysfunction is also observed in the swollen axons of the white matter of individuals with severe Alzheimer's dementia.Synonyms: RIC4, SNAP, SNAP-25, SUP, Super Protein, Synaptosomal-associated 25 kDa protein, Synaptosomal-associated protein 25, ric-4
    基因ID
    6616
    NCBI登录号
    NP_003072
    UniProt
    P60880
    途径
    Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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