Myelin Basic Protein (MBP) (AA 84-89) 抗体

ABIN119023 产品详细信息, 供应商: Log in to see
抗原
  • cb274
  • fj33b11
  • mbp
  • wu:fj33b11
  • wu:fq15b02
  • zgc:136630
  • MGC115135
  • Mbps
  • C76307
  • Hmbpr
  • R75289
  • golli-mbp
  • mld
  • shi
  • myelin basic protein a
  • myelin basic protein
  • mbpa
  • mbp
  • MBP
  • Mbp
抗原表位
AA 84-89
15
11
7
6
6
6
5
5
4
4
4
4
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
适用
人, 哺乳动物
157
51
42
40
15
14
13
11
5
5
5
4
4
4
3
2
2
1
宿主
小鼠
90
70
15
9
1
1
克隆类型 (克隆位点)
单克隆 ()
标记
非结合性
5
5
4
3
3
2
1
应用范围
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
123
78
63
41
30
25
24
14
12
7
7
6
6
4
3
3
1
选项
Supplier
Log in to see
Supplier Product No.
Log in to see
免疫原 Human myelin basic protein. Spleen cells from immunised mice were fused with cells of the mouse SP2/0 myeloma cell line.
克隆位点 22
亚型 IgG2b
特异性 This antibody recognises an epitope of Human myelin basic protein between amino acids 84-89. Reacts with MBP from most species.
纯化方法 Supernatant
别名 Myelin Basic Protein (MBP Antibody 摘要)
背景 The classic group of Myelin basic protein (MBP) isoforms (isoforms 4 to 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non classic group of MBP isoforms (isoforms 1 to 3/Golli MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.Synonyms: MBP, Myelin membrane encephalitogenic protein
基因ID 4155
NCBI登录号 NP_001020252
UniProt P02686
研究领域 Glia marker, Cell/Tissue Markers
应用备注 Immunohistochemistry on frozen sections. Immunohistochemistry on paraffin sections. Recommended positive control: Brain. Has been reported to work in Western blotting.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
状态 Liquid
缓冲液 0.09 % Sodium Azide
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freezing and thawing.
储存条件 4 °C/-20 °C
储存方法 Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
厂商提供的图像
Immunohistochemistry (IHC) image for anti-Myelin Basic Protein (MBP) (AA 84-89) antibody (ABIN119023) Staining of white matter in human brain with Mouse anti MBP
背景 Liao, Ahmed, Smith, Van Nostrand: "Degradation of amyloid beta protein by purified myelin basic protein." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 28917-25, 2009 (PubMed).

Harrower, Tyers, Hooks, Barker: "Long-term survival and integration of porcine expanded neural precursor cell grafts in a rat model of Parkinson's disease." in: Experimental neurology, Vol. 197, Issue 1, pp. 56-69, 2005 (PubMed).

Groome, Dawkes, Barry, Hruby, Alvord: "New monoclonal antibodies reactive with defined sequential epitopes in human myelin basic protein." in: Journal of neuroimmunology, Vol. 19, Issue 4, pp. 305-15, 1988 (PubMed).

您还需要查找其他产品吗?