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CD72 抗体

CD72 适用: 人 FACS, IP 宿主: 小鼠 Monoclonal 3F3 unconjugated
产品编号 ABIN118793
发货至: 中国
  • 抗原 See all CD72 抗体
    CD72 (CD72 Molecule (CD72))
    适用
    • 46
    • 19
    • 1
    宿主
    • 37
    • 20
    • 1
    小鼠
    克隆类型
    • 37
    • 21
    单克隆
    标记
    • 26
    • 7
    • 7
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    • 3
    • 3
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    This CD72 antibody is un-conjugated
    应用范围
    • 29
    • 24
    • 22
    • 8
    • 7
    • 6
    • 3
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    • 2
    • 2
    • 2
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    Flow Cytometry (FACS), Immunoprecipitation (IP)
    特异性
    The antibody reacts with CD72, a 39-43 kDa type II membrane glycoprotein (C-type lectin family).
    纯化方法
    Precipitation methods and ion exchange chromatography
    纯度
    > 95 % (by SDS-PAGE)
    免疫原
    Normal human lymphocytes from a lymph node
    克隆位点
    3F3
    亚型
    IgG2b
    Top Product
    Discover our top product CD72 Primary Antibody
  • 应用备注
    Immunoprecipitation. Flow Cytometry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing. Dilute only prior to immediate use
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody (undiluted) at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    CD72 (CD72 Molecule (CD72))
    别名
    CD72 (CD72 产品)
    别名
    CD72c antibody, Ly-19 antibody, Ly-32 antibody, Ly-m19 antibody, Lyb-2 antibody, CD72b antibody, LYB2 antibody, CD72 antigen antibody, CD72 molecule antibody, Cd72 antibody, CD72 antibody
    背景
    CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation. CD72 is a pan-B cell marker expressed throughout the B lymphocytes diferentiation with the exception of plasma cells, it is also present on follicular dendritic cells.Synonyms: B-Cell marker, B-cell differentiation antigen CD72, Ly-32, Ly32, Lyb-2, Lymphocyte antigen 32
    基因ID
    971
    NCBI登录号
    NP_001773
    UniProt
    P21854
    途径
    BCR Signaling
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