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CD39 抗体 (PE)

ENTPD1 适用: 人 FACS 宿主: 小鼠 Monoclonal A1 PE
产品编号 ABIN118627
发货至: 中国
  • 抗原 See all CD39 (ENTPD1) 抗体
    CD39 (ENTPD1) (Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1))
    适用
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    宿主
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    小鼠
    克隆类型
    • 40
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    单克隆
    标记
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    This CD39 antibody is conjugated to PE
    应用范围
    • 36
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    Flow Cytometry (FACS)
    特异性
    This antibody binds to the Human CD39 cell surface antigen, a 70-100 kDa molecule expressed on peripheral blood B cells, monocytes and T cell clones. CD39 has intrinsic ecto-ATPase activity. Expression is induced on T cells and increased on B cells as a late activation antigen. This antibody has been shown to block MHC independent target cell recognition by hapten-specific CTL. SM1101A is recommended for this purpose (Ref.8).
    纯化方法
    Affinity Chromatography on Protein G.
    免疫原
    PHA activated human lymphocytes
    克隆位点
    A1
    亚型
    IgG1
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  • 应用备注
    Flow Cytometry: Use 10 μL of neat antibody to label 10^6 cells in 100 μL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This antibody has been shown to block MHC independent target cell recognition by hapten- specific CTL. ABIN118624 is recommended for this purpose (8).
    限制
    仅限研究用
  • 溶解方式
    Restore with 1.0 mL distilled water.
    浓度
    0.1 mg/mL
    缓冲液
    PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    This product is photosensitive and should be protected from light
    储存条件
    4 °C
    储存方法
    Prior to and following reconstitution store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
  • 抗原
    CD39 (ENTPD1) (Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1))
    别名
    CD39 / ENTPD1 (ENTPD1 产品)
    别名
    ATPDase antibody, CD39 antibody, NTPDase-1 antibody, MGC80631 antibody, zgc:100819 antibody, entpd1 antibody, MGC79567 antibody, 2610206B08Rik antibody, AA408691 antibody, Cd39 antibody, ectonucleoside triphosphate diphosphohydrolase 1 antibody, ectonucleoside triphosphate diphosphohydrolase 1 L homeolog antibody, ENTPD1 antibody, Entpd1 antibody, entpd1.L antibody, entpd1 antibody
    背景
    Human CD39 is found on most mature B cells, activated NK cells and activated T cells. CD39 is also weakly expressed on granulocytes. CD39 has homology to the Nmyc family of proteins and was recently cloned. CD39 can hydrolyze both nucleoside triphosphates and diphosphates. CD39 is the dominant ecto nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type 2 purinergic (P2) G protein coupled receptors (GPCRs). CD39 transgenic mice exhibit impaired platelet aggregation, prolonged bleeding times, and resistance to systemic thromboembolism. There is a correlation between ATP hydrolysis and triglycerides in patients with chronic heart disease, suggesting a relationship between ATP diphosphohydrolase and thrombogenesis. Depolarization causes the endothelial production of superoxide, which inhibits the activity of endothelial CD39 and enhances platelet aggregation. After exercise, all subjects showed a significant reduction of CD39 expression in platelet and an increase of CD39 expression in B lymphocytes.Synonyms: ATPDase, Ecto-ATP diphosphohydrolase, Ecto-apyrase, Ectonucleoside triphosphate diphosphohydrolase 1, Lymphoid cell activation antigen, NTPDase 1
    基因ID
    953
    NCBI登录号
    NP_001091645
    UniProt
    P49961
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