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TCR gamma/delta 抗体 (FITC)

TCR gamma/delta 适用: 小鼠 FACS, IHC (p) 宿主: 仓鼠 Monoclonal GL3 FITC
产品编号 ABIN118357
发货至: 中国
  • 抗原 See all TCR gamma/delta products
    TCR gamma/delta (T-Cell Receptor gamma/delta (TCR gamma/delta))
    适用
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    小鼠
    宿主
    • 34
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    • 2
    仓鼠
    克隆类型
    • 59
    单克隆
    标记
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    This TCR gamma/delta antibody is conjugated to FITC
    应用范围
    • 59
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    Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    Affinity Chromatography on Protein A
    免疫原
    C57BL/6J intra epithelial lymphocytes. Spleen cells from an immunised Armenian hamster were fused with cells of the murine myeloma SP2/0 myeloma cell line.
    克隆位点
    GL3
    亚型
    IgG
  • 应用备注
    Flow Cytometry: The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    0.1 mg/mL
    缓冲液
    Contains 0.09 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    TCR gamma/delta (T-Cell Receptor gamma/delta (TCR gamma/delta))
    别名
    T Cell Receptor / TCR gamma/delta (TCR gamma/delta 产品)
    背景
    T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment, a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas.Synonyms: T-Cell Receptor delta, T-Cell Receptor gamma, T-Cell Receptor gamma delta, TCRD, TCRG
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