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SKP1 抗体 (C-Term)

Name: SKP1 抗体 (C-Term)
SKU: ABIN117959
Availability: OutOfStock

SKP1 适用: 人 WB, IP, EIA 宿主: 兔 Polyclonal unconjugated

Conjugation pathways for ubiquitin and ubiquitin-like m(UBLs).

1 image

(1 reference)

产品编号 ABIN117959

发货至: 中国

Datasheet as PDF

抗原 See all SKP1 抗体

SKP1 (S-Phase Kinase-Associated Protein 1 (SKP1))
抗原表位
15

7

7

6

4

3

3

1

1

1

1

1

1

1

1
AA 152-163, C-Term
适用
53

40

38

4

2

2

2

1

1

1

1

1

1
人
宿主
62

6
兔
Compatible Secondaries
克隆类型
53

15
多克隆
标记
31

5

4

3

3

3

3

3

3

3

1

1

1

1

1

1

1
This SKP1 antibody is un-conjugated
应用范围
47

27

14

13

10

9

6

4

4

3

2

1

1
Western Blotting (WB), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

序列

Human SKP1 (163 aa 18.5 kDa) 1 mpsiklqssd geifevdvei akqsvtiktm ledlgmddeg dddpvplpnv naailkkviq 61 wcthhkddpp ppeddenkek rtddipvwdq eflkvdqgtl felilaanyl dikglldvtc 121 ktvanmikgk tpeeirktfn ikndfteeee aqvrkenqwc eek

特异性

This product is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration. This product reacts with human SKP1. Cross reactivity is expected against mouse SKP1 based on a high degree of sequence homology. Cross reactivity with other SKP1 proteins or SKP1 from other sources is not known.

纯化方法

Delipidation and defibrination.

免疫原

Prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 152-163 of Human SKP1 (C-terminus) coupled to KLH.

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anti-S-Phase Kinase-Associated Protein 1 (SKP1) (AA 1-163) antibody
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anti-S-Phase Kinase-Associated Protein 1 (SKP1) antibody
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anti-S-Phase Kinase-Associated Protein 1 (SKP1) (AA 1-163) antibody
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anti-S-Phase Kinase-Associated Protein 1 (SKP1) (AA 1-160) antibody
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anti-S-Phase Kinase-Associated Protein 1 (SKP1) (AA 81-163) antibody
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应用备注

ELISA (1/2,000-1/10,000). This antibody reacts with human SKP1 by Western blot(1/500-1/1,000) and Immunoprecipitation. The antibody Immunoprecipitates in vitrotranslated protein and protein from cell lysates (using HeLa, NIH-3T3, and others). Coimmunoprecipitation of cyclin A and Cuol1 may occur. An 18.5 kDa band correspondingto human SKP1 is detected. Most cell lines expressing SKP1 can be used as a positivecontrol.

限制

仅限研究用
状态

Liquid

浓度

85.0 mg/mL (by Refractometry)

储存条件

4 °C

储存方法

Store undiluted at 2-8 °C.
Wang, He, Wang, Wang, Zhai, Zhou, Zhang, Zhai, Feng, Han: "[Impact of Donor KIR2DS5 Genotype on Outcome Following Haploidentical Hematopoietic Stem Cell Transplantation.]" in: Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology, Vol. 16, Issue 1, pp. 111-5, (2008) (PubMed).
抗原

SKP1 (S-Phase Kinase-Associated Protein 1 (SKP1))

别名

SKP1 / OCP2 (SKP1 产品)

背景

SKP1 is also known as S-phase kinase-associated protein 1A, Cyclin A/CDK2-associated protein p19, p19A, p19skp1, RNA polymerase II elongation factor-like protein, Organ of Corti protein 2, OCP-II protein, OCP-2, Transcription elongation factor B, and SIII. SKP1 is an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, SKP1 serves as an adapter that links the F-box protein to CUL1. SKP1 interacts directly with CUL1 and F-box proteins, such as BTRC and SKP2, in the SCF complex. SKP1 also interacts with FBX29 and the cyclin A/CDK2 complex. SKP1 is part of a SCF-like complex consisting of CUL7, RBX1, SKP1 and FBXW8 and is also a component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1A, APC and TBL1X.Synonyms: Cyclin A/CDK2-associated protein p19, EMC19, OCP-2, OCP-II, Organ of Corti protein 2, RNA polymerase II elongation factor-like protein, S-phase kinase-associated protein 1, SKP1A, TCEB1L, Transcription elongation factor B, p19A, p19skp1

基因ID

6500

NCBI登录号

NP_008861

UniProt

P63208

途径

Cell Division Cycle, Hedgehog Signaling, Mitotic G1-G1/S Phases