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AKT2 抗体

AKT2 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN117900
发货至: 中国
  • 抗原 See all AKT2 抗体
    AKT2 (V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2))
    适用
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    人, 小鼠, 大鼠
    宿主
    • 166
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    克隆类型
    • 167
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    多克隆
    标记
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    This AKT2 antibody is un-conjugated
    应用范围
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    Western Blotting (WB)
    序列
    Synthetic peptide R-Y-D-S-L-G-L-L-E-L-D-Q-R-T (correspond ing to aa 455-468 of 481)
    特异性
    This affinity purified antibody is directed against human AKT2. The antibody detects both unphosphorylated and phosphorylated forms of the protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification. Cross reactivity with AKT2 from other species has not been determined, however, the sequence of the immunogen shows 85 % identity to mouse and 92 % identity with rat, therefore, cross reactivity is expected.
    纯化方法
    Immunoaffinity purification.
    免疫原
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide of human AKT2 conjugated to Keyhole Limpet Hemocyanin (KLH).
    Top Product
    Discover our top product AKT2 Primary Antibody
  • 应用备注
    This antibody was tested by ELISA and Immunoblotting and was found to be reactive withboth unphosphorylated and phosphorylated AKT2 in a lysate of HEK293 cells. Although nottested, this antibody is likely functional in Immunohistochemistry andImmunoprecipitation. Recommended Dilution(s): This product has been assayed by immunoblot against aHEK293 cell lysate and is reactive at a 1: 1,000 dilution showing a band at approximately 60
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 , with 0.01 % Sodium Azide as preservative.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store undiluted at 2-8 °C.
  • 抗原
    AKT2 (V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2))
    别名
    AKT2 / PKB beta (AKT2 产品)
    别名
    AKT2 antibody, pkbb antibody, pkbbeta antibody, pkbss antibody, prkbb antibody, rac-beta antibody, v-akt2 antibody, 2410016A19Rik antibody, AW554154 antibody, PKB antibody, PKBbeta antibody, HIHGHH antibody, PKBB antibody, PKBBETA antibody, PRKBB antibody, RAC-BETA antibody, cb945 antibody, akt2-a antibody, AKT serine/threonine kinase 2 antibody, v-akt murine thymoma viral oncogene homolog 2 antibody, thymoma viral proto-oncogene 2 antibody, v-akt murine thymoma viral oncogene homolog 2 L homeolog antibody, AKT2 antibody, akt2 antibody, Akt2 antibody, akt2.L antibody
    背景
    AKT2 is also known as V-AKT Murine Thymoma Viral Oncogene Homolog 2 antibody, Rac protein kinase beta antibody, PKB beta antibody or PRKBB antibody. AKT2 is an isoform of the phosphoinositidedependent serine-threonine protein kinase AKT and is enriched in insulin-responsive tissues and has been implicated in the metabolic actions of the hormone. AKT2 is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2- like) domains. Furthermore, AKT2 was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression of AKT2 contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. AKT2 is a general protein kinase capable of phophorylating several known proteins. AKT2 mediates many of the downstream events of PI 3-kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI 3-kinase recruits AKT2 to the membrane, where it is activated by PDK1 phosphorylation. Once phosphorylated, AKT2 dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus. AKT2 has two main roles: (i) inhibition of apoptosis, (ii) promotion of proliferation.Synonyms: Protein kinase Akt-2, Protein kinase B beta, RAC-PK-beta, RAC-beta serine/threonine-protein kinase
    基因ID
    208
    NCBI登录号
    NP_001617
    UniProt
    P31751
    途径
    PI3K-Akt Signaling, RTK signaling, AMPK Signaling, TLR signaling, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Hepatitis C, VEGF Signaling
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