HLA-ABC (HLA-ABC) 抗体

ABIN1177256 产品详细信息, 供应商: Log in to see
抗原
  • HLAA
  • major histocompatibility complex, class I, A
  • HLA-A
适用

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宿主
小鼠
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4
克隆类型 (克隆位点)
单克隆 ()
标记
非结合性
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应用范围
Blocking Reagent (BR), Flow Cytometry (FACS)
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选项
Supplier
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Supplier Product No.
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品牌 BD Pharmingen™
免疫原 Polyclonal Human NK Cell Line
克隆位点 DX17
亚型 IgG1, kappa
纯化方法 The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
过滤 0.2 μm filtered
内毒素水平 Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
别名 HLA-A/B/C (HLA-ABC Antibody 摘要)
背景 The DX17 monoclonal antibody reacts with a monomorphic epitope expressed on all HLA (human leukocyte antigen) class I molecules examined. DX17 immunoprecipitates HLA class I heavy chains (45 kDa) and beta2-microglobulin (12kDa) from radiolabeled human cell lines. HLA is determined by a complex segment of the short arm of chromosome 6 and there are many human HLAs encoded in this segment. The antigenic agglomerate is called MHC, for major histocompatibility complex. Examples of class I loci are HLA-A, -B, and -C, which are serologically assayed, class II loci, e.g., HLA-D/DR and DC1, are tested by lymphocytotoxic methods.
途径 TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
限制 仅限研究用
状态 Liquid
浓度 1.0 mg/mL
缓冲液 No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
储存液 Azide free
储存条件 4 °C
储存方法 Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
厂商提供的图像
Flow Cytometry (FACS) image for anti-HLA-ABC (HLA-ABC) antibody (ABIN1177256) anti-HLA-ABC (HLA-ABC) antibody
有引用在: Gumperz, Litwin, Phillips, Lanier, Parham: "The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor." in: The Journal of experimental medicine, Vol. 181, Issue 3, pp. 1133-44, 1995 (PubMed).

Lanier, Gumperz, Parham, Melero, López-Botet, Phillips: "The NKB1 and HP-3E4 NK cells receptors are structurally distinct glycoproteins and independently recognize polymorphic HLA-B and HLA-C molecules." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 7, pp. 3320-7, 1995 (PubMed).

Morton, Kirsch, Nance, Evans, Korman, Strominger: "Orientation of loci within the human major histocompatibility complex by chromosomal in situ hybridization." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, Issue 9, pp. 2816-20, 1984 (PubMed).

Bach, Amos: "Hu-1: Major histocompatibility locus in man." in: Science (New York, N.Y.), Vol. 156, Issue 3781, pp. 1506-8, 1970 (PubMed).