CD247 抗体 (pTyr142) (Alexa Fluor 488)
(1 reference)-
- 抗原 See all CD247 抗体
- CD247 (CD247 Molecule (CD247))
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抗原表位
- pTyr142
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适用
- 人, 小鼠, 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CD247 antibody is conjugated to Alexa Fluor 488
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应用范围
- Intracellular Staining (ICS)
- 品牌
- BD Phosflow™
- 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Phosphorylated Human CD3zeta Peptide
- 克隆位点
- K25-407-69
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product CD247 Primary Antibody
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anti-CD247 Molecule (CD247) (Tyr72) antibody
CD247 适用: 人, 小鼠 WB, FACS, ICC 宿主: 小鼠 Monoclonal EM-26 unconjugated
anti-CD247 Molecule (CD247) (AA 1-164) antibodyCD247 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-CD247 Molecule (CD247) (AA 1-164) antibodyCD247 适用: 人 WB, ELISA, IP, IHC (p) 宿主: 小鼠 Monoclonal 4A12-F6 unconjugated
anti-CD247 Molecule (CD247) (AA 88-153) antibodyCD247 适用: 人 WB, ELISA, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-CD247 Molecule (CD247) (AA 50-164) antibodyCD247 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CD247 Molecule (CD247) antibodyCD247 适用: 人 WB, ELISA, FACS, IHC, ICC 宿主: 小鼠 Monoclonal 4B10 unconjugated
anti-CD247 Molecule (CD247) (AA 1-165) antibodyCD247 适用: 人 WB, IP, IHC (p), EIA 宿主: 小鼠 Monoclonal 4A12-F6 unconjugated
anti-CD247 Molecule (CD247) (AA 51-100) antibodyCD247 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-CD247 Molecule (CD247) (N-Term) antibodyCD247 适用: 人 WB, FACS 宿主: 兔 Polyclonal unconjugated
anti-CD247 Molecule (CD247) (C-Term) antibodyCD247 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
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- 样本量
- 20 μL
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- The antibody was conjugated to Alexa Fluor® 647 under optimum conditions, and unreacted Alexa Fluor® 647 was removed. Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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: "Differential signaling by lymphocyte antigen receptors." in: Annual review of immunology, Vol. 15, pp. 125-54, (1997) (PubMed).
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: "Differential signaling by lymphocyte antigen receptors." in: Annual review of immunology, Vol. 15, pp. 125-54, (1997) (PubMed).
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- 抗原
- CD247 (CD247 Molecule (CD247))
- 别名
- CD247 (CD247 产品)
- 别名
- CD3-ZETA antibody, CD3H antibody, CD3Q antibody, CD3Z antibody, T3Z antibody, TCRZ antibody, 4930549J05Rik antibody, A430104F18Rik antibody, AW552088 antibody, Cd3 antibody, Cd3-eta antibody, Cd3-zeta antibody, Cd3h antibody, Cd3z antibody, Cd3zeta antibody, T3z antibody, Tcrk antibody, Tcrz antibody, LOC100136514 antibody, LOC100136549 antibody, LOC100305023 antibody, CD247 antibody, TCRzeta antibody, CD247 molecule antibody, CD247 antigen antibody, CD3zeta-2 antibody, CD3zeta-1 antibody, Cd247 molecule antibody, CD247 antibody, Cd247 antibody, cd3z antibody, cd247 antibody
- 背景
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The T cell receptor (TCR), expressed by thymocytes and T lymphocytes, is a multi-component cell-surface complex responsible for recognizing antigen in the context of MHC molecules. The antigen-specific binding component of the TCR, Ti, is a heterodimer of the variable Ig-like subunits a and b or g and d. Ti is non-covalently associated with an invariant set of molecules referred to as the CD3 polypeptides, g, d, e, and zeta. The CD3 z polypeptide (CD3z) was named CD247 at the 7th Human Leukocyte Differentiation Antigens Workshop. CD3 appears early in thymocyte differentiation and remains expressed on all mature T lymphocytes. After antigen recognition by the TCR, CD3z is the primary intracellular signal transducing subunit. It contains three ITAMs (Immunoreceptor Tyrosine-based Activation Motifs), each of which contains a pair of tyrosine residues that are phosphorylated by Lck and Fyn and are required for signal propagation. The molecular weight of CD3z is 16 kDa, and it is also observed as 32-kDa homodimers or as heterodimers with the g chain of Fc receptors. Upon phosphorylation, the CD3z monomer undergoes an apparent shift in electrophoretic mobility up to 21 kDa. The K25-407.69 monoclonal antibody recognizes the phosphorylated tyrosine 142 (pY142) in the third ITAM domain of human CD3z (CD247).
Synonyms: CD3zeta - 途径
- TCR Signaling, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway
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