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ITGA2 抗体

ITGA2 适用: 小鼠 FACS, IP, BR 宿主: Armenian Hamster Monoclonal HMalpha2 unconjugated
产品编号 ABIN1176973
发货至: 中国
  • 抗原 See all ITGA2 抗体
    ITGA2 (Integrin alpha 2 (ITGA2))
    适用
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    小鼠
    宿主
    • 82
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    Armenian Hamster
    克隆类型
    • 81
    • 75
    单克隆
    标记
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    This ITGA2 antibody is un-conjugated
    应用范围
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    Flow Cytometry (FACS), Immunoprecipitation (IP), Blocking Reagent (BR)
    品牌
    BD Pharmingen™
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    过滤
    0.2 μm filtered
    内毒素水平
    Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
    免疫原
    Mouse colon carcinoma cell line Colon26
    克隆位点
    HMalpha2
    亚型
    IgG1 kappa
    Top Product
    Discover our top product ITGA2 Primary Antibody
  • 应用备注
    For immunohistochemical staining, we recommend the use of purified anti-rat CD49b mAb Ha1/29, which cross-reacts with mouse, Cat. No. 559987/554998.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    Aqueous buffered solution containing no preservative, 0.2μm filtered. Endotoxin level is ≤0.01 ng/μg of protein.
    储存液
    Azide free
    储存条件
    4 °C
    储存方法
    This preparation contains no preservatives, thus it should be handled under aseptic conditions. Store undiluted at 4° C.
  • Arase, Saito, Phillips, Lanier: "Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 3, pp. 1141-4, (2001) (PubMed).

    Chen, Paul: "A population of CD62Llow Nk1.1- CD4+ T cells that resembles NK1.1+ CD4+ T cells." in: European journal of immunology, Vol. 28, Issue 10, pp. 3172-82, (1998) (PubMed).

    Tanaka, Ohtsuka, Yagita, Shiratori, Omata, Okumura: "Involvement of alpha 1 and alpha 4 integrins in gut mucosal injury of graft-versus-host disease." in: International immunology, Vol. 7, Issue 8, pp. 1183-9, (1996) (PubMed).

    Noto, Kato, Okumura, Yagita: "Identification and functional characterization of mouse CD29 with a mAb." in: International immunology, Vol. 7, Issue 5, pp. 835-42, (1995) (PubMed).

    Miyake, Sakurai, Okumura, Yagita: "Identification of collagen and laminin receptor integrins on murine T lymphocytes." in: European journal of immunology, Vol. 24, Issue 9, pp. 2000-5, (1994) (PubMed).

  • 抗原
    ITGA2 (Integrin alpha 2 (ITGA2))
    别名
    CD49b (ITGA2 产品)
    别名
    BR antibody, CD49B antibody, GPIa antibody, HPA-5 antibody, VLA-2 antibody, VLAA2 antibody, DX5 antibody, integrin subunit alpha 2 antibody, integrin alpha 2 antibody, ITGA2 antibody, Itga2 antibody
    背景
    The HMalpha2 antibody reacts with integrin alpha2 chain (CD49b), the 150-kDa transmembrane glycoprotein that non-covalently associates with the integrin beta1 subunit (CD29) to form the integrin alpha2beta1 complex known as VLA-2. VLA-2, a receptor for collagen and laminin, is expressed on some splenic CD4+ T lymphocytes and NK-T cells, intestinal intraepithelial and lamina propria lymphocytes, splenic NK cells, epithelial cells, and platelets, but it is not on thymocytes or Peyer’s-patch or lymphnode lymphocytes. The expression of VLA-2 is upregulated on lymphocytes in response to mitogens. The HMalpha2 antibody has been reported to partially block the interaction of T-cell blasts, but not NK cells, with collagen. Purified HMalpha2 mAb blocks the staining of splenic NK cells by the anti-CD49b/Pan-NK Cells mAb DX5 (Cat. No. 553858, for the PE conjugate). Therefore, mAb HMalpha2 may be used like the DX5 mAb for identification of NK cells.
    Synonyms: Integrin alpha2 chain
    途径
    CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Integrin Complex
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