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p130 抗体 (C-Term)

RBL2 适用: 人, 大鼠, 小鼠 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN116943
发货至: 中国
  • 抗原 See all p130 (RBL2) 抗体
    p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))
    抗原表位
    • 15
    • 10
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    • 7
    • 7
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 74
    • 28
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    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
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    • 1
    人, 大鼠, 小鼠
    宿主
    • 66
    • 8
    克隆类型
    • 66
    • 8
    多克隆
    标记
    • 33
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
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    • 1
    • 1
    This p130 antibody is un-conjugated
    应用范围
    • 35
    • 30
    • 14
    • 13
    • 13
    • 7
    • 7
    • 5
    • 4
    • 3
    • 1
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    Antiserum will specifically react with a 130 kDa Rb2 protein from Human, Rat and Mouse tissue. No reaction was observed against other related tumor supressor proteins. Cross reactivity with Rb2 (p130) from other species may also occur.
    纯化方法
    Delipidation and Defibrination.
    免疫原
    Rb2 (p130) peptide corresponding to the C-terminus of the Human protein conjugated to Keyhole Limpet Hemocyanin (KLH). Genename: RBL2
    Top Product
    Discover our top product RBL2 Primary Antibody
  • 应用备注
    Suitable for ELISA, Immunoprecipitation, Immunoblotting and other immunologicalmethods requiring high titer and specificity. Recommended Dilutions: ELISA: 1/500-1/20,000. Western Blot: 1/500-1/2,000. Immunoprecipitation: 1/100. Immunohistochemistry on Paraffin Embedded Tissue: 1/200-1/1,000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    85 mg/mL (by Refractometry)
    缓冲液
    0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2 with 0.01 % sodium azide as preservative.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))
    别名
    RBL2 / p130 (RBL2 产品)
    别名
    RBL2 antibody, RBR2 antibody, RRB2a antibody, PRB2 antibody, RBR-2 antibody, Rb2 antibody, p130 antibody, P130 antibody, retinoblastoma-like 2 (p130) antibody, RB transcriptional corepressor like 2 antibody, related to retinoblastoma 2 antibody, RBL2 antibody, LOC541652 antibody, Rbl2 antibody
    背景
    P130/pRb2, p107 and Rb together make up the Rb family of cell cycle regulatory proteins. As a family of proteins, the different members share several structural and functional features which include two distinct "pocket domains", interaction with viral gene products, interaction with members of the E2F family of proteins and changes in phosphorylation states leading to modulation of activity and cell cycle expression. The p130 protein is ubiquitously expressed with highest levels in terminally differentiated cells where it presumably functions to maintain the cells in a G0 state and as such has been used as a marker for G0. Depending on position within the cell cycle, p130 can exist in 4 different forms as a function of phosphorylation with Form 0 being the unphosphorylated form and the other three forms being referred to as Forms 1-3 correlating with increasing degrees of phosphorylation. Changes in levels of p130 expression have been reported in several cancers including endometrial, small cell lung, and neuroblastoma.Synonyms: 130 kDa retinoblastoma-associated protein, RB2, RBR-2, Retinoblastoma-like protein 2, Retinoblastoma-related protein 2, p130, pRb2
    基因ID
    5934
    NCBI登录号
    NP_005602
    UniProt
    Q08999
    途径
    Cell Division Cycle, Mitotic G1-G1/S Phases
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