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LEFTY2 抗体

LEFTY2 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 小鼠 Monoclonal 7C5G1H6H10 unconjugated
产品编号 ABIN116931
发货至: 中国
  • 抗原 See all LEFTY2 抗体
    LEFTY2 (Left-Right Determination Factor 2 (LEFTY2))
    适用
    • 30
    • 13
    • 10
    • 3
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 33
    • 5
    • 2
    • 1
    小鼠
    克隆类型
    • 36
    • 5
    单克隆
    标记
    • 26
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LEFTY2 antibody is un-conjugated
    应用范围
    • 33
    • 15
    • 14
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    特异性
    This protein A purified mouse monoclonal antibody reacts with a 30 kDa protein corresponding to human LEFTY. No reactivity occurs against 6X HIS tag. Significant sequence homology exists between the human and mouse forms of LEFTY. Cross reactivity is expected with mouse and rat forms of the protein. Reactivity with other sources has not been determined.
    纯化方法
    Protein A chromatography.
    免疫原
    A BALB/c mouse was immunized with a recombinant form of 6X HIS tagged human LEFTY.
    克隆位点
    7C5G1H6H10
    亚型
    IgG2a
    Top Product
    Discover our top product LEFTY2 Primary Antibody
  • 应用备注
    This antibody is suitable for ELISA (1/5,000) and Western blotting (1/2,000). The antibodymay be used for other applications, such as RIA, Immunohistochemistry orImmunoprecipitation, but specific reaction conditions have not been developed.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL (by UV absorbance at 280 nm)
    缓冲液
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01 % sodium azide as preservative.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody (undiluted) at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    LEFTY2 (Left-Right Determination Factor 2 (LEFTY2))
    别名
    LEFTY2 (LEFTY2 产品)
    别名
    EBAF antibody, LEFTA antibody, LEFTYA antibody, TGFB4 antibody, AI450052 antibody, Ebaf antibody, Leftb antibody, Stra3 antibody, Tgfb4 antibody, lefty antibody, lefty-1 antibody, atv2 antibody, cb720 antibody, fe38b03 antibody, wu:fe38b03 antibody, 6030463A22Rik antibody, AV214969 antibody, Lefta antibody, Ebaf2 antibody, left-right determination factor 2 antibody, left right determination factor 1 antibody, lefty2 antibody, Left-right determination factor 2 antibody, left-right determination factor 2-like antibody, LEFTY2 antibody, Lefty1 antibody, lft2 antibody, Lefty2 antibody, LOC699676 antibody, LOC100232580 antibody
    背景
    During vertebrate embryogenesis, a left-right axis is established. Secreted growth factors of the TGF-beta family, including gene products derived from nodal, lefty-1 and lefty-2, play crucial roles in establishing left-right asymmetries. TGF-beta (Transforming growth factor-beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells. TGF-beta actions are directed by ligand-induced activation of TGF-beta receptors. Complexes formed move into the nucleus, where they act as components of a transcriptional complex. Lefty, a novel member of the TGF-beta superfamily, inhibits TGF-beta signaling. Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF-beta receptor. Lefty also inhibits events downstream from R-Smad phosphorylation. Lefty provides a repressed state of TGF-beta-responsive genes. The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, and Lefty A and Lefty B in humans. Members of the TGF-beta superfamily require processing for their activation. Cleavage is therefore an essential step for Lefty activation. Lefty is synthesized as a large inactive precursor (42 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms). The 28 kDa form induces MAPK activity.Synonyms: EBAF, Endometrial bleeding-associated factor, LEFTA, LEFTY2, LEFTYA, Left-right determination factor 2, Left-right determination factor A, Protein lefty-2, Protein lefty-A, TGF-beta-4, TGFB4, Transforming growth factor beta-4
    基因ID
    7044
    NCBI登录号
    NP_003231
    UniProt
    O00292
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