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Interleukin 33 抗体 (IL33)

Details for Product anti-IL33 Antibody No. ABIN1169168, 供应商: Log in to see
抗原
  • IL33
  • C9orf26
  • DVS27
  • IL1F11
  • NF-HEV
  • NFEHEV
  • RP11-575C20.2
  • 9230117N10Rik
  • Il-33
  • Il1f11
  • RGD1311155
  • interleukin 33
  • interleukin 33-like
  • interleukin-33-like
  • IL33
  • Il33
  • LOC100356081
  • LOC100518643
Alternatives
anti-小鼠 Interleukin 33 抗体 for Cell Culture
适用
小鼠
290
105
45
8
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3
2
2
宿主
小鼠
188
132
24
23
4
3
2
1
1
抗体类型
Recombinant Antibody
克隆类型 (克隆位点)
单克隆 ()
标记
This Interleukin 33 antibody is un-conjugated
36
19
14
14
8
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5
5
5
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4
4
3
3
3
3
3
3
3
3
3
3
1
1
1
1
1
1
1
应用范围
ELISA, Functional Studies (Func)
279
214
89
61
45
24
21
21
16
14
13
10
7
5
5
4
3
3
2
2
2
1
1
Supplier
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免疫原 Mouse recombinant IL-33.
克隆位点 Bondy-1-1
亚型 IgG2b
特异性 Recognizes mouse IL-33.
交叉反应 小鼠
纯化方法 Purified from HEK 293 cell culture supernatant.
纯度 >95 % (SDS-PAGE)
内毒素水平 <0.01EU/μg purified protein (LAL test, Lonza).
别名 IL-33 (IL33 Antibody 摘要)
背景 Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL-33 binds to and signals through ST2 (IL-1R1) and its stimulation recruits MYD88, IRAK, IRAK4 and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14) and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases and sepsis. Anti-IL-33, mAb (recombinant) (blocking) (Bondy-1-1) is an antibody developed by antibody phage display technology using a human naive antibody gene library. These libraries consist of scFv (single chain fragment variable) composed of VH (variable domain of the human immunoglobulin heavy chain) and VL (variable domain of the human immunoglobulin light chain) connected by a polypeptide linker. The antibody fragments are displayed on the surface of filamentous bacteriophage (M13). This scFv was selected by affinity selection on antigen in a process termed panning. Multiple rounds of panning are performed to enrich for antigen-specific scFv-phage. Monoclonal antibodies are subsequently identified by screening after each round of selection. The selected monoclonal scFv is cloned into an appropriate vector containing a Fc portion of interest and then produced in mammalian cells to generate an IgG like scFv-Fc fusion protein.
UniProt Q8BVZ5
途径 Production of Molecular Mediator of Immune Response
应用备注 Optimal working dilution should be determined by the investigator.
说明

anti-IL-33 (mouse), monoclonal antibody (recombinant) (Bondy-1-1) is composed of human variable regions (VH and VL) (lambda-chain) of immunoglobulin fused to the mouse lgG2b Fc domain.

限制 仅限研究用
状态 Liquid
浓度 1 mg/mL
缓冲液 In PBS containing 10 % glycerol and 0.02 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C,-20 °C
储存方法 Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.
有效期 12 months
厂商提供的图像
ELISA image for anti-Interleukin 33 抗体 (IL33) (ABIN1169168) Binding of IL-33 (mouse) to ST2/IL-1RAcP is inhibited by IL-33 (mouse), mAb (rec.) (b...