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Endoglin 抗体 (AA 26-581)

ENG 适用: 小鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN115700
发货至: 中国
  • 抗原 See all Endoglin (ENG) 抗体
    Endoglin (ENG)
    抗原表位
    • 16
    • 14
    • 12
    • 12
    • 7
    • 7
    • 7
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    • 1
    • 1
    • 1
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    AA 26-581
    适用
    • 171
    • 61
    • 44
    • 17
    • 10
    • 3
    • 2
    • 1
    小鼠
    宿主
    • 106
    • 86
    • 16
    • 1
    • 1
    克隆类型
    • 106
    • 103
    • 1
    多克隆
    标记
    • 91
    • 27
    • 25
    • 25
    • 15
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    This Endoglin antibody is un-conjugated
    应用范围
    • 148
    • 125
    • 58
    • 57
    • 34
    • 19
    • 17
    • 15
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    Western Blotting (WB), Enzyme Immunoassay (EIA)
    纯化方法
    Protein A Chromatography (+his tag depleted)
    免疫原
    Highly pure recombinant Mouse soluble CD105 produced in Insect cells. The recombinant soluble CD105 consists of amino acid 26(Glu) to 581 (Gly) and is fused to a C-terminal His-tag (6xHis).
    Top Product
    Discover our top product ENG Primary Antibody
  • 应用备注
    ELISA (1-15 μg/mL). Western blot (1-2 μg/mL). Flow Cytometry (3-20 μg/mL).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 溶解方式
    Restore with sterile water to a concentration of 0.1-1.0 mg/mL
    缓冲液
    PBS, pH 7.2 without preservatives
    储存液
    Without preservative
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Prior to reconstitution store at 2-8 °C. Following reconstitution store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. For extended storage add glycerol to 50%.
  • 抗原
    Endoglin (ENG)
    别名
    CD105 / Endoglin (ENG 产品)
    别名
    ENG antibody, MGC137842 antibody, DKFZp469D0419 antibody, END antibody, HHT1 antibody, ORW1 antibody, AI528660 antibody, AI662476 antibody, CD105 antibody, S-endoglin antibody, endoglin antibody, ENG antibody, Eng antibody
    背景
    Endoglin, also known as CD105, is a Type I integral membrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated, cytoplasmic tail. Two splice variants of human endoglin, the S-endoglin and L-endoglin that differ in the length of their cytoplasmic tails have been identified. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, bone marrow pro-erythroblasts, and leukemic cells of lymphoid and myeloid lineages. Human and mouse endoglin share approximately 70 % and 97 % amino acid sequence identity in their extracellular and intracellular domains, respectively. It has clearly been shown that CD105/Endoglin is required for angiogenesis and it plays a key role in heart evelopment. Mutations in human endoglin or ALK-1 (another type I serine/threonine receptor) lead to the vascular isorder hereditary hemorrhagic telangiectasia (HHT). Mice heterozygous for endoglin have been developed as disease models for HHT. Endoglin has been shown to be a powerful marker of neovascularization. It is also useful as a functional marker that defines long-term repopulating hematopoietic stem cells.Synonyms: END, ENG, HHT1, ORW, ORW1
    基因ID
    10090
    UniProt
    Q63961
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