兔 anti-人 Ig (Chain lambda), (Light Chain) Antibody
IHC (fro), IHC (p)
Polyclonal
unconjugated
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- 抗原 See all Ig products
- Ig
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抗原表位
- Chain lambda, Light Chain
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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应用范围
- Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- Purified
- 免疫原
- Lambda light chains isolated from pooled urine of patients with Bence Jones proteinuria
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Rabbit anti-Human Ig (Chain kappa), (Light Chain), (N-Term) antibody
IHC (fro), IHC (p) Monoclonal A21-Y unconjugated
Rabbit anti-Human Ig (C-Term), (Chain kappa), (Light Chain) antibodyIHC (fro), IHC (p) Monoclonal H16-E unconjugated
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- 应用备注
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Immunohistochemistry on formalin-fixed paraffin embedded sections: dilute 1: 250-1: 1000in an ABC method (incubation time: 30 minutes at room temperature). Recommended positive control: Tonsil
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 状态
- Liquid
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- Ig
- 别名
- Immunoglobulin (Ig 产品)
- 背景
- All five immunoglobulin classes share the same basic four polypeptide chain structure of two heavy-chains and two light chains. There are five heavy chain types, and two light-chain types (Kappa and Lambda) both having a molecular weight of 22.5 kDa. Any heavy-chain type can associate with either light-chain type, but on any immunoglobulin molecule both light-chains are of the same type. Kappa and Lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region. The ratio of Kappa to Lambda is 70:30 , the vast majority of which is bound to heavy-chain in immunoglobulin. In normal individuals low levels of free light-chain arepresent in serum (kappa, 1.6-15.2 mg/L, Lambda, 0.4-4.2 mg/L), with the occurrence of multiple myeloma or other B-cell malignancies these levels can be greatly elevated and can be found at high levels in the urine (Bence-Jones proteins).
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