APOB 抗体 (Apolipoprotein B) (HRP)

Details for Product anti-APOB Antibody No. ABIN112988, 供应商: Log in to see
抗原
  • FLDB
  • LDLCQ4
  • Ac1-060
  • Apo B-100
  • ApoB-100
  • ApoB-48
  • AI315052
  • apob-100
  • apob-48
  • APOB-100
  • ApoB(100)
  • APOB
  • apolipoprotein B
  • apolipoprotein B (including Ag(x) antigen)
  • APOB
  • Apob
适用

338
37
26
8
3
1
1
1
宿主
山羊
150
120
77
8
3
克隆类型
多克隆
标记
This APOB antibody is conjugated to HRP
25
21
15
13
13
12
1
1
1
1
1
1
1
1
1
1
1
1
应用范围
Enzyme Immunoassay (EIA), Western Blotting (WB)
231
159
67
56
46
34
21
21
19
14
14
13
8
7
3
2
2
1
1
1
1
1
1
1
选项
Supplier
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Supplier Product No.
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免疫原 Human LDL.
特异性 Binds to Human Apo B-48/100. No cross- reaction with human Apo AI, Apo AII, Apo CI, Apo CII, Apo CIII and Apo E.
纯化方法 Human Apolipoprotein B-100 Sepharose Affinity Chromatography.
别名 Apolipoprotein B (Apo B) (APOB Antibody 摘要)
背景 Apolipoprotein B consists of a single polypeptide chain with a molecular weight of 549 kDa and is mostly synthesised in the liver. It is a major apolipoprotein of very low density, intermediate density and low density lipoproteins (LDL) as well as being a major component of lipoprotein (a). Apolipoprotein B is a ligand for the LDL receptor and elevated levels are associated with premature atherosclerosis. Normal plasma apolipoprotein B levels are around 800 mg/l.Synonyms: Apo-B, ApoB, ApoB-100, ApoB100
基因ID 338
NCBI登录号 NP_000375
UniProt P04114
研究领域 Metabolism
应用备注 Can be used to detect the existence of Apo B-48/100 in plasma and lipoproteins forImmunoassay and Immunoblot. Dilution range for Immunoblot and ELISA: 2,500-10,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
状态 Liquid
溶解方式 Restore with 1.0 mL distilled water. Centrifuge product if not completely clear after standing for 1-2 hours at room temperature.
浓度 1.0 mg/mL (prior to lyophilization)
缓冲液 50 mM PBS, 0.1 M Sodium Chloride, pH 7.4 containing 10 mg/mL BSA as stabilizer and 0.01 % Thimerosal as preservative.
储存液 Thimerosal (Merthiolate)
注意事项 This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Dilute only prior to immediate use
储存条件 4 °C
储存方法 Store the antibody undiluted for one month at 2-8 °C or (mix with an equal volume of Glycerol) at -20 °C for longer. Avoid cycles of freezing and thawing.
背景 Ng, Bourquard, Grijalva, Hama, Shih, Navab, Fogelman, Lusis, Young, Reddy: "Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2." in: The Journal of biological chemistry, Vol. 281, Issue 40, pp. 29491-500, 2006 (PubMed).

Schneider, Witztum, Young, Ludwig, Miller, Tsimikas, Curtiss, Marcovina, Taylor, Lawn, Innerarity, Pitas: "High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins." in: Journal of lipid research, Vol. 46, Issue 4, pp. 769-78, 2005 (PubMed).

Reardon, Miller, Blachowicz, Lukens, Binder, Witztum, Getz: "Autoantibodies to OxLDL fail to alter the clearance of injected OxLDL in apolipoprotein E-deficient mice." in: Journal of lipid research, Vol. 45, Issue 7, pp. 1347-54, 2004 (PubMed).

Kitchens, Thompson, Munford, OKeefe: "Acute inflammation and infection maintain circulating phospholipid levels and enhance lipopolysaccharide binding to plasma lipoproteins." in: Journal of lipid research, Vol. 44, Issue 12, pp. 2339-48, 2003 (PubMed).

Herscovitz, Derksen, Walsh, McKnight, Gantz, Hadzopoulou-Cladaras, Zannis, Curry, Small: "The N-terminal 17% of apoB binds tightly and irreversibly to emulsions modeling nascent very low density lipoproteins." in: Journal of lipid research, Vol. 42, Issue 1, pp. 51-9, 2001 (PubMed).

Lin, Gordon, Wetterau: "Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression." in: Journal of lipid research, Vol. 36, Issue 5, pp. 1073-81, 1995 (PubMed).

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