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PLIN2 抗体 (Perilipin 2) (AA 5-27) (FITC)

Details for Product anti-PLIN2 Antibody No. ABIN112186, 供应商: Log in to see
抗原
  • adfp
  • adrp
  • fatvg
  • MGC76047
  • adipophilin
  • PLIN2
  • ADFP
  • DKFZp469F1012
  • ADRP
  • AA407157
  • ADPH
  • Adfp
  • Adrp
  • perilipin-2
  • perilipin 2
  • adipophilin
  • Adipophilin
  • plin2
  • LOC100304704
  • adfp
  • PLIN2
  • Plin2
Alternatives
anti-大鼠 PLIN2 抗体 for ELISA
抗原表位
AA 5-27, N-Term
25
23
21
19
19
13
12
10
8
7
6
5
4
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
适用
犬, 人, 大鼠
200
59
21
10
7
6
6
1
宿主
小鼠
101
84
15
3
2
克隆类型 (克隆位点)
单克隆 ()
标记
This PLIN2 antibody is conjugated to FITC
11
9
8
6
6
5
5
4
4
4
4
4
3
3
2
2
2
2
2
1
应用范围
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
164
86
85
77
73
68
67
12
3
2
2
2
2
2
2
Supplier
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免疫原 Synthetic peptide corresponding to aa 5-27 from N-terminus of Human Adipophilin.
克隆位点 AP125
亚型 IgG1
特异性 Tissue Immunolocalization: Adipophilin is positively detected in the glandular cells of lactating mammary gland (ductal cells are negative), zona fasciculata of the adrenal gland, Sertoli cells of the testis, and in fat-accumulating hepatocytes of alcoholic cirrhotic fatty liver, adipocytes are negative. Also positively stained are lipid-storing CD68-positive macrophages. Polypeptide Reacting: Adipophilin / ADRP, MW 48,100 (calculated from aa sequence data), apparent Mr 52,000 (after SDS-PAGE), pI 6.72 Tested Reactivities on Cultured Cell Lines: Caco, PLC, HaCat, SV80, RD 125, Huvec (human umbilical cord endothelia), RV, PC-12 (rat adrenal gland), MDCK, negative with glioma.
交叉反应 (详细) Species reactivity (tested):Human, Rat and Canine (Dog).Negative with Bovine and Mouse.
纯化方法 Immunoaffinity Chromatography.
别名 Adipophilin / ADFP (PLIN2 Antibody 摘要)
背景 Adipophilin / ADRP is a ubiquitous component of lipid droplets. It has been found in milk fat globule membranes and on the surface of lipid droplets in various cultured cell lines (see e.g. Heid et al., for review see e.g. Targett-Adams et al.), inducible by etomoxir. Enhanced expression of Adipophilin / ADRP is a useful marker for pathologies characterized by increased lipid droplet accumulation. Such diseases include atheroma, steatosis, obesity and certain cases of liposarcoma. It also seems to be a potent marker for atherosclerosis. ADRP can also be used to study the virus entry of e.g. HCV via lipid droplets (see e.g. Hope et al.).Synonyms: ADRP, Adipose differentiation-related protein
基因ID 123
NCBI登录号 NP_001113
UniProt Q99541
研究领域 Metabolism
途径 Regulation of Lipid Metabolism by PPARalpha
应用备注 FACS. Cytological Material. Immunohistochemistry on Frozen Sections: 1/10-1/20 in PBS ( pH 7.4)Incubation Time: 1 h at room temperature or over night at 2-8 °C. Immunohistochemistry on Paraffin Sections (after microwave treatment).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
状态 Liquid
浓度 0.2 mg/mL
缓冲液 PBS
注意事项 Avoid repeated freezing and thawing.
储存条件 4 °C/-20 °C
储存方法 Store the antibody undiluted at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.
背景 Ostermeyer, Paci, Zeng, Lublin, Munro, Brown: "Accumulation of caveolin in the endoplasmic reticulum redirects the protein to lipid storage droplets." in: The Journal of cell biology, Vol. 152, Issue 5, pp. 1071-8, 2001 (PubMed).

Hope, McLauchlan: "Sequence motifs required for lipid droplet association and protein stability are unique to the hepatitis C virus core protein." in: The Journal of general virology, Vol. 81, Issue Pt 8, pp. 1913-25, 2000 (PubMed).

Heid, Moll, Schwetlick, Rackwitz, Keenan: "Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases." in: Cell and tissue research, Vol. 294, Issue 2, pp. 309-21, 1998 (PubMed).

Heid, Schnölzer, Keenan: "Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane." in: The Biochemical journal, Vol. 320 ( Pt 3), pp. 1025-30, 1997 (PubMed).