IL1RN 抗体
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- 抗原 See all IL1RN 抗体
- IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This IL1RN antibody is un-conjugated
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应用范围
- Enzyme Immunoassay (EIA)
- 纯化方法
- Affinity Chromatography.
- 免疫原
- Recombinant human IL-1Ra.
- 克隆位点
- 1384-92
- 亚型
- IgG1
- Top Product
- Discover our top product IL1RN Primary Antibody
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anti-Interleukin 1 Receptor Antagonist (IL1RN) antibody
IL1RN 适用: 人 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 1 Receptor Antagonist (IL1RN) (AA 26-177) antibodyIL1RN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 1 Receptor Antagonist (IL1RN) (AA 26-177) antibodyIL1RN 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Interleukin 1 Receptor Antagonist (IL1RN) (AA 1-159) antibodyIL1RN 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1H5 unconjugated
anti-Interleukin 1 Receptor Antagonist (IL1RN) (AA 147-177), (C-Term) antibodyIL1RN 适用: 人 WB, IF, FACS 宿主: 兔 Polyclonal RB18902 unconjugated
anti-Interleukin 1 Receptor Antagonist (IL1RN) (AA 27-178) antibodyIL1RN 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 1 Receptor Antagonist (IL1RN) (AA 100-129) antibodyIL1RN 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB18901 unconjugated
anti-Interleukin 1 Receptor Antagonist (IL1RN) (AA 24-174) antibodyIL1RN 适用: Cow WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 1 Receptor Antagonist (IL1RN) (AA 26-177) antibodyIL1RN 适用: 兔 WB, IHC, IP, ICC 宿主: 豚鼠 Polyclonal unconjugated
anti-Interleukin 1 Receptor Antagonist (IL1RN) (AA 26-177) antibodyIL1RN 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C7 unconjugated
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- 应用备注
- Suitable for ELISA. Distribution: The antigen is produced and secreted by monocytes and macrophages afterstimulation with pro-inflammatory cytokines, LPS, and in vitro by immunoglobulins coated
- 限制
- 仅限研究用
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- 溶解方式
- Restore with 0.5 mL distilled water (stock solution).
- 浓度
- 0.4 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.2 containing 0.01 % Thimerosal as a preservative and no stabilizer.
- 储存液
- Thimerosal (Merthiolate)
- 注意事项
- This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.
- 储存条件
- -20 °C
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- 抗原
- IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))
- 别名
- IL1RN / IL1RA (IL1RN 产品)
- 别名
- DIRA antibody, ICIL-1RA antibody, IL-1RN antibody, IL-1ra antibody, IL-1ra3 antibody, IL1F3 antibody, IL1RA antibody, IRAP antibody, MVCD4 antibody, IRAP1 antibody, IL1RN antibody, IL-1RA antibody, F630041P17Rik antibody, interleukin 1 receptor antagonist antibody, interleukin 1 receptor antagonist-like antibody, IL1RN antibody, Il1rn antibody, IL1RNL antibody
- 背景
- The interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring molecule that shares homology with IL-1α and IL-1β. It binds competitively to IL-1 receptors Type I and Type II with the same affinity as does IL-1, but does not induce any intracellular response. Two structural variants of IL-1Ra have been described: a 17 kDa form that is secreted from monocytes, macrophages, neutrophils, and other cells (sIL-1Ra) and an 18- kDa form that remains in the cytoplasm of keratinocytes and other epithelial cells, monocytes, and fibroblasts (icIL-1Ra). An additional 16- kDa intracellular isoform of IL-1Ra has recently been described in neutrophils, monocytes, and hepatic cells. Both of the major isoforms of IL-1Ra are transcribed from the same gene through the use of alternative first exons. The production of IL-1Ra is stimulated by many substances including adherent IgG, other cytokines, and bacterial or viral components. The tissue distribution of IL-1Ra in mice indicates that sIL-1Ra is found predominantely in peripheral blood cells, lungs, spleen, and liver, while icIL-1Ra is found in large amounts in skin. Studies in transgenic and knockout mice indicate that IL-1Ra is important in host defense against endotoxin-induced injury. IL-1Ra is produced by hepatic cells with the characteristics of an acute phase protein. Endogenous IL-1Ra is produced in numerous experimental animal models of diesease as well as in human autoimmune and chronic inflammatory diseases. The use of neutralizing anti-IL-1Ra antibodies has demonstrated that endogenous IL-1Ra is an important natural antiinflammatory protein in arthritis, colitis, and granulomatous pulmonary disease.Synonyms: ICIL-1RA, IL-1RN, IL-1ra, IL1 inhibitor, IL1F3, IRAP, Interleukin-1 receptor antagonist protein
- 基因ID
- 9606
- UniProt
- P18510
- 途径
- NF-kappaB Signaling, Hormone Transport, Cancer Immune Checkpoints
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