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Desmoplakin 抗体

DSP 适用: 人, 小鼠, 大鼠, Cow, 小鸡, 犬, Amphibian WB, IHC (fro), IF 宿主: 小鼠 Monoclonal DP2-15 unconjugated
产品编号 ABIN111818
发货至: 中国
  • 抗原 See all Desmoplakin (DSP) 抗体
    Desmoplakin (DSP)
    适用
    • 32
    • 15
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, Cow, 小鸡, 犬, Amphibian
    宿主
    • 28
    • 3
    • 2
    小鼠
    克隆类型
    • 30
    • 3
    单克隆
    标记
    • 22
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Desmoplakin antibody is un-conjugated
    应用范围
    • 14
    • 11
    • 11
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)
    特异性
    This antibody reacts to Desmoplakin 1&2. It shows distinct punctate membrane staining of different epithelia. Tumors Specifically Detected: Primary and metastatic carcinoma and meningioma. Polypeptides Reacting: Desmoplakin 1 and 2 (Mr 250 000 and 215 000). Reactivity on Tested Cell Lines: Several Human carcinoma cell lines: MCF-7, A-431, Rat MHC1C1 cell line, Bovine cells: MDBK, BMGE.
    交叉反应 (详细)
    Species reactivity (tested):Human, Bovine, Rat, Mouse and Chicken.
    纯化方法
    Affinity Chromatography on Protein A
    免疫原
    Bovine Desmoplakin 1 and 2
    克隆位点
    DP2-15
    亚型
    IgG1
    Top Product
    Discover our top product DSP Primary Antibody
  • 应用备注
    Immunoblotting. Immunofluorescence. Immunohistochemistry on Frozen Sections: Dilute 1/10 with PBS, pH 7.4 (Incubation Time: 1 h at RT).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 溶解方式
    Restore in 1 mL dist. water.
    缓冲液
    Final solution contains PBS, pH 7.4, 0.09 % Sodium Azide, 0.5 % BSA
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Prior to reconstitution store at 2-8 °C. Following reconstitution store the antibody (in aliquots) at -20 °C.
  • 抗原
    Desmoplakin (DSP)
    别名
    Desmoplakin (DSP 产品)
    别名
    DP antibody, DPI antibody, DPII antibody, DSP antibody, dpi antibody, dpii antibody, 2300002E22Rik antibody, 5730453H04Rik antibody, AA407887 antibody, AA407888 antibody, AW109828 antibody, im:6911953 antibody, sb:cb570 antibody, wu:fc17a08 antibody, wu:fk73d01 antibody, desmoplakin antibody, Desmoplakin antibody, ORF113 antibody, desmoplakin a antibody, ORF112 DESMOPLAKIN antibody, orf102 antibody, orf91; similar to Cydia pomonella granulovirus orf112 antibody, ORF62 antibody, ORF-66 antibody, ORF57 antibody, agip105 antibody, similar to XcORF133; similar to HaGV desmoplakin antibody, desmoplakin L homeolog antibody, ORF96 antibody, DSP antibody, PhopGV104 antibody, ORF-59 desmoplakin antibody, desmop antibody, Dsp antibody, dsp antibody, desmoplakin antibody, dspa antibody, orf112 desmoplakin antibody, ClgVgp102 antibody, COGV_gp091 antibody, APNV_p087 antibody, CBNV_gp066 antibody, EONV_gp057 antibody, OLNV_gp066 antibody, AgipMNPV_gp105 antibody, HaMNV_gp106 antibody, EupsNPV_gp065 antibody, PsunGV_gp139 antibody, dsp.L antibody, ClanGV_gp096 antibody
    背景
    Desmosomes are intercellular junctions that form tight links between adjacent cells. Desmoplakin is an obligate component of functional desmosomes that attaches intermediate filaments to desmosomal plaques. It is involved in the organization of desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains. The N-terminus of desmoplakin is essential for localisation to the desmosome and interaction with plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds to intermediate filaments. The central region of desmoplakin comprises a coiled-coil rod domain that mediates homodimerisation. There are two isoforms of desmoplakin - desmoplakin I, which is an obligate component of all desmosomes, and desmoplakin II, which is predominantly expressed in tissues and cells of stratified origin. Mutations in the gene encoding desmoplakin result in a number of cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.Synonyms: 250/210 kDa paraneoplastic pemphigus antigen, DP, DSP
    基因ID
    1832
    NCBI登录号
    NP_001008844
    UniProt
    P15924
    途径
    Cell-Cell Junction Organization
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