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TJP1 抗体 (AA 886-995)

TJP1 适用: 人, 小鼠, 大鼠, 犬 WB, IF, FACS, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1109613
发货至: 中国
  • 抗原 See all TJP1 抗体
    TJP1 (Tight Junction Protein 1 (TJP1))
    抗原表位
    • 16
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 886-995
    适用
    • 52
    • 31
    • 29
    • 20
    • 18
    • 8
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, 犬
    宿主
    • 48
    • 3
    • 2
    • 1
    • 1
    克隆类型
    • 50
    • 5
    多克隆
    标记
    • 37
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TJP1 antibody is un-conjugated
    应用范围
    • 50
    • 19
    • 18
    • 15
    • 14
    • 13
    • 11
    • 11
    • 10
    • 7
    • 7
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    This antibody recognizes specifically ZO-1 alpha-plus.
    交叉反应 (详细)
    Species reactivity (tested):Human, Mouse, Rat, Dog.
    纯化方法
    Protein A Chromatography
    免疫原
    Amino acids 886-995 of human ZO-1
    亚型
    Ig Fraction
    Top Product
    Discover our top product TJP1 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.1 mg/mL
    缓冲液
    PBS, 0.02 % Sodium Azide, 0.1 % BSA
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store undiluted at 2-8 °C.
  • 抗原
    TJP1 (Tight Junction Protein 1 (TJP1))
    别名
    ZO-1 / Tight Junction Protein 1 (TJP1 产品)
    别名
    ZO-1 antibody, ZO1 antibody, zo1 antibody, tight junction protein 1 antibody, tight junction protein ZO-1 antibody, TJP1 antibody, Tjp1 antibody, LOC396567 antibody
    背景
    Zona occludens 1 (ZO-1) is an ~220 kDa tight junction protein belonging to the membrane-associated guanlyate kinase (MAGUK) family. Members of this family are involved in epithelial and endothelial intercellular junctions. They each contain at least one PSD95/Dlg/ZO-1 (PDZ) domain, a Src homology 3 (SH3) domain, and an enzymatically inactive guanylate kinase domain. PDZ domains are 90-amino acid protein-protein binding domains that recognize at least a 3-residue peptide motif in the COOH termini of their binding partners. PDZ domain-containing proteins, like ZO-1, typically act as scaffolding proteins that organize membrane receptors and cytosolic proteins into multimeric signaling complexes often at the sites of cell-cell contact. The effectiveness and stability of the epithelial barrier depends on a complex of proteins composing different intercellular junctions, which include tight junctions, adherens junctions, and desmosomes. ZO-1 is a peripheral membrane protein bound on the cytoplasmic surface of junctional contacts and is expressed in all tight junctions regardless of their properties. ZO-1 immunoprecipitates with its family member ZO-2. ZO-1 was shown to undergo tyrosine phosphorylation during tight junction formation and remodeling. Two different isoforms of ZO-1, alpha-minus and alpha-plus, have been described, which result from alternative splicing of an mRNA encoded by a single gene. The ZO-1 alpha-plus contains an 80 amino acids motif called alpha which is not present in ZO-1 alpha-minus. The alpha-containing isoform is found in most epithelial cell junctions. The short isoform (ZO-1 alpha-minus) is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules. This difference in distribution provides molecular distinction among tight junctions.Synonyms: Tjp1, Zo1, Zona occludens protein 1, Zonula occludens protein 1
    基因ID
    7082
    NCBI登录号
    NP_003248
    UniProt
    Q07157
    途径
    Carbohydrate Homeostasis, Cell-Cell Junction Organization
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