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TREM2 抗体

TREM2 适用: 小鼠 IP, EIA 宿主: 大鼠 Monoclonal 6-00E-009 unconjugated
产品编号 ABIN1109326
发货至: 中国
  • 抗原 See all TREM2 抗体
    TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))
    适用
    • 58
    • 41
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    小鼠
    宿主
    • 59
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    大鼠
    克隆类型
    • 60
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    单克隆
    标记
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    This TREM2 antibody is un-conjugated
    应用范围
    • 53
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    • 9
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    Immunoprecipitation (IP), Enzyme Immunoassay (EIA)
    特异性
    The monoclonal antibody 6E9 recognizes membrane-bound as well as soluble triggering receptor expressed on myeloid cells-2 (TREM-2).
    交叉反应 (详细)
    Species reactivity (tested):Mouse
    纯化方法
    Purified
    免疫原
    Mouse recombinant TREM-2 protein
    克隆位点
    6-00E-009
    亚型
    IgG2b
    Top Product
    Discover our top product TREM2 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.1 mg/mL
    缓冲液
    PBS, 02 % Sodium Azide, 0.1 % BSA
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store undiluted at 2-8 °C.
  • 抗原
    TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))
    别名
    TREM2 (TREM2 产品)
    别名
    TREM-A1 antibody, TREM-B1 antibody, TREM2 antibody, trem-2 antibody, trem2a antibody, trem2b antibody, trem2c antibody, TREM-2 antibody, Trem2a antibody, Trem2b antibody, Trem2c antibody, triggering receptor expressed on myeloid cells 2 antibody, trem-like transcript 2 protein antibody, TREM2 antibody, trem2 antibody, LOC100228399 antibody, Trem2 antibody
    背景
    TREM-2 is a 26 kDa transmembrane glycoprotein that consists of a single extracellular immunoglobulin-like domain, a transmembrane region with a charged lysine residue and a short cytoplasmic tail. It associates with DNAX-activation protein 12 (DAP12) for signaling and function. TREM-2 is expressed on immature monocyte-derived dendritic cells. After activation by microbial products or tumor necrosis factor (TNF) and TNF-related proteins, dendritic cells downregulate the expression of TREM-2. TREM-2 is also expressed by osteoclasts and microglia, where it is involved in bone modeling and brain function, respectively. Another role of TREM-2 might be promoting the removal of apoptotic cells, organic matrix and macromolecules by microglia. Defects in TREM-2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD). TREM-2, like TREM-1, can be cleaved on the membrane to release a soluble form of TREM-2 (sTREM-2). Elevated levels of sTREM-2 in CSF of multiple sclerosis patients have been detected. This elevated level may inhibit the anti-inflammatory function of the membrane-bound receptor suggesting sTREM-2 to be a possible target for future therapies.Synonyms: TREM-2, Trem2a, Trem2b, Trem2c, Triggering receptor expressed on monocytes 2, Triggering receptor expressed on myeloid cells 2
    基因ID
    83433
    NCBI登录号
    NP_112544
    UniProt
    Q99NH8
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