Podocalyxin-Like (PODXL) 抗体 (FITC)

ABIN1108687 产品详细信息, 供应商: Log in to see
抗原
  • PODXL
  • podxl
  • fc18d02
  • wu:fc18d02
  • Gp200
  • PC
  • PCLP
  • PCLP-1
  • AW121214
  • Ly102
  • Pclp1
  • podocalyxin
  • Gp135
  • PCLP1
  • cPCLP1
  • MEP21
  • Podxl
  • podocalyxin-like
  • si:dkey-146n1.1
  • podocalyxin-like protein 1
  • PODXL
  • si:dkey-146n1.1
  • LOC100614602
  • Podxl
  • LOC100512201
  • PCLP1
适用
小鼠
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宿主
大鼠
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克隆类型 (克隆位点)
单克隆 ()
标记
FITC
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应用范围
Flow Cytometry (FACS)
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选项
Supplier
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Supplier Product No.
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免疫原 LO cells
克隆位点 10B9
亚型 IgG1
特异性 This antibody reacts with mouse Podocalyxin /PCLP1 (LO).
纯化方法 Protein G agarose
别名 Podocalyxin / PODXL (PODXL Antibody 摘要)
背景 Recent studies with avian embryos and murine embryonic stem cells have suggested that hematopoietic cells are derived from hemangioblasts, the common precursors of hematopoietic and endothelial cells. Hara et al. molecularly cloned podocalyxin-like protein 1 (PCLP1) as a novel surface marker for endothelial-like cells in the AGM (aorta-gonad-mesonephros) region of mouse embryos, where long-term repopulating hematopoietic stem cells (LTR-HSCs) are known to arise. PCLP1+CD45- cells in the AGM region incorporated acetylated low-density lipoprotein and produced both hematopoietic and endothelial cells when cocultured with OP9 stromal cells. Moreover, multiple lineages of hematopoietic cells were generated in vivo when PCLP1+ CD45- cells were injected into neonatal liver of busulfan-treated mice. Anti-Mouse PCLP1 stains LO cells as well as the endothelial-like cells in the AGM culture. LO cell is a novel OSM (oncostatin M)-dependent cell line which exhibits characteristics similar to endothelial-like cells. Today it is reported that the PCLP1 is identical with the Podocalyxin.Synonyms: GCTM-2 antigen, Hematopoietic Stem Cell Marker, PCLP, PCLP-1, PCLP1, Podocalyxin-like protein 1
基因ID 27205
NCBI登录号 NP_038751
UniProt Q9R0M4
途径 Tube Formation
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
状态 Liquid
浓度 20 µg/mL
缓冲液 PBS, 0.09 % NaN3, 1 % BSA
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C
储存方法 Store at 2 - 8 °C.
厂商提供的图像
Flow Cytometry (FACS) image for anti-Podocalyxin-Like (PODXL) antibody (FITC) (ABIN1108687) anti-Podocalyxin-Like (PODXL) antibody (FITC)
背景 Doyonnas, Nielsen, Chelliah, Drew, Hara, Miyajima, McNagny: "Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells." in: Blood, Vol. 105, Issue 11, pp. 4170-8, 2005 (PubMed).

Minegishi, Suzuki, Yokomizo, Pan, Fujimoto, Takahashi, Hara, Miyajima, Nishikawa, Yamamoto: "Expression and domain-specific function of GATA-2 during differentiation of the hematopoietic precursor cells in midgestation mouse embryos." in: Blood, Vol. 102, Issue 3, pp. 896-905, 2003 (PubMed).

Minehata, Mukouyama, Sekiguchi, Hara, Miyajima: "Macrophage colony stimulating factor modulates the development of hematopoiesis by stimulating the differentiation of endothelial cells in the AGM region." in: Blood, Vol. 99, Issue 7, pp. 2360-8, 2002 (PubMed).

Hara, Nakano, Tanaka, Tamura, Sekiguchi, Minehata, Copeland, Jenkins, Okabe, Kogo, Mukouyama, Miyajima: "Identification of podocalyxin-like protein 1 as a novel cell surface marker for hemangioblasts in the murine aorta-gonad-mesonephros region." in: Immunity, Vol. 11, Issue 5, pp. 567-78, 2000 (PubMed).

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