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Mesothelin 抗体 (MSLN) (PE)

Details for Product anti-MSLN Antibody No. ABIN1108213, 供应商: Log in to see
抗原
  • MSLN
  • CEPR
  • CMKRL2
  • DRY12
  • FEG-1
  • GPCR-Br
  • GPER
  • GPR30
  • LERGU
  • LERGU2
  • LyGPR
  • 6330420K13Rik
  • Ceprl
  • Gper
  • Gpr30
  • MPF
  • SMRP
  • mesothelin
  • G protein-coupled estrogen receptor 1
  • mesothelin-like
  • MSLN
  • GPER1
  • Gper1
  • Msln
  • LOC100524016
Alternatives
anti-小鼠 Mesothelin 抗体 for ELISA
适用
小鼠
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6
3
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2
1
1
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1
宿主
大鼠
116
52
25
15
1
克隆类型 (克隆位点)
单克隆 ()
标记
This Mesothelin antibody is conjugated to PE
12
10
8
4
3
3
3
3
3
2
1
1
1
1
1
1
1
1
1
1
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1
应用范围
Flow Cytometry (FACS)
117
73
52
42
40
13
7
7
4
4
3
3
2
2
2
2
1
1
Supplier
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免疫原 Murine hemangioblast-like cell lineLO
克隆位点 295D
亚型 IgG2a
特异性 This antibody reacts with Mesothelin.
交叉反应 (详细) Species reactivity (tested):Mouse (LO). Does not work with human (Jurkat).
纯化方法 Protein G agarose
别名 Mesothelin (MSLN Antibody 摘要)
背景 Mesothelin (MSLN) is a GPI-linked cell surface glycoprotein expressed in the mesothelial lining of the body cavities and in mullerian duct epithelium related cancer cells (ovarian, pancreatic cancer, mesothelioma). Both human and mouse mesothelin bind to ovarian cancer antigen CA125/MUC16 with high affinity, mediating cell attachment in vitro, suggesting that mesothelin may facilitate ovarian cancer metastasis.Synonyms: CAK1 antigen, MPF, MSLN, Pre-pro-megakaryocyte-potentiating factor
基因ID 56047
NCBI登录号 NP_061345
UniProt Q61468
研究领域 Cancer
途径 EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
状态 Liquid
缓冲液 PBS, 0.09 % Sodium Azide, 1 % BSA
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C
储存方法 Store at 2 - 8 °C.
厂商提供的图像
Flow Cytometry (FACS) image for anti-Mesothelin 抗体 (MSLN)  (PE) (ABIN1108213) anti-Mesothelin (MSLN) antibody (PE)
背景 Ho, Hassan, Zhang, Wang, Onda, Bera, Pastan: "Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 11, Issue 10, pp. 3814-20, 2005 (PubMed).

Rump, Morikawa, Tanaka, Minami, Umesaki, Takeuchi, Miyajima: "Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion." in: The Journal of biological chemistry, Vol. 279, Issue 10, pp. 9190-8, 2004 (PubMed).

Nakayama, Hara, Hibi, Hirano, Miyajima: "A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth." in: The Journal of biological chemistry, Vol. 274, Issue 35, pp. 24766-72, 1999 (PubMed).

Kojima, Oh-eda, Hattori, Taniguchi, Tamura, Ochi, Yamaguchi: "Molecular cloning and expression of megakaryocyte potentiating factor cDNA." in: The Journal of biological chemistry, Vol. 270, Issue 37, pp. 21984-90, 1995 (PubMed).