LY96 抗体 (FITC)
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- 抗原 See all LY96 抗体
- LY96 (Lymphocyte Antigen 96 (LY96))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This LY96 antibody is conjugated to FITC
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA), Functional Studies (Func)
- 无交叉反应
- 小鼠
- 交叉反应 （详细）
- Species reactivity (tested):Human.
- 纯化方法
- Protein G
- 免疫原
- Baculovirally expressed His-tagged human MD-2
- 克隆位点
- 4H1
- 亚型
- IgG1
- Top Product
- Discover our top product LY96 Primary Antibody
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anti-Lymphocyte Antigen 96 (LY96) (AA 16-160) antibody
LY96 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte Antigen 96 (LY96) (AA 19-130) antibodyLY96 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte Antigen 96 (LY96) (AA 19-160) antibodyLY96 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Lymphocyte Antigen 96 (LY96) (AA 2-160) antibodyLY96 适用: 人 WB, IHC (p) 宿主: 小鼠 Monoclonal 9F1B1 unconjugated
anti-Lymphocyte Antigen 96 (LY96) (AA 1-160) antibodyLY96 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte Antigen 96 (LY96) (AA 1-160) antibodyLY96 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Lymphocyte Antigen 96 (LY96) (AA 19-160) antibodyLY96 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte Antigen 96 (LY96) (AA 19-160) antibodyLY96 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte Antigen 96 (LY96) (AA 86-135) antibodyLY96 适用: 人, 小鼠, 大鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.1 mg/mL
- 缓冲液
- PBS, 1 % bovine serum albumin
- 储存条件
- 4 °C
- 储存方法
- Store at 2 - 8 °C.
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- 抗原
- LY96 (Lymphocyte Antigen 96 (LY96))
- 别名
- MD-2 (LY96 产品)
- 别名
- MD2 antibody, ESOP-1 antibody, MD-2 antibody, ly-96 antibody, Ly-96 antibody, Md2 antibody, lymphocyte antigen 96 antibody, LY96 antibody, Ly96 antibody
- 背景
- TLRs belong to a family of proteins that specifically recognizes and senses microbial products. They are highly conserved throughout evolution and act as innate immune recognition receptors against many pathogens. TLR4 is a functional receptor for gram-negative bacterial lipopolysaccharides (LPS). TLR4 associates with MD-2 which is absolutely required for LPS-induced activation of TLR4. MD-2 exists as a cell surface protein in association with TLR4. It also exists as secreted forms consisting of MD-2 monomers and multimers. Circulating sMD-2 is mainly present as a doublet of ~20 and 25 kD, representing differentially glycosylated forms. Unlike TLR4, sMD-2 binds directly LPS without the need of soluble CD14 (sCD14). However, LPS-MD-2 interactions are increased when LPS is pretreated with CD14. Only monomeric sMD-2 is biologically active and able to associate with TLR4 and LPS. sMD-2 circulates in plasma of healthy individuals as a non-active, polymeric protein. In septic plasma, the total amount of sMD-2 was strongly elevated and contained both sMD-2 polymers and monomers. Soluble MD-2 is proposed to be an important mediator of organ inflammation during sepsis. During experimental human endotoxemia, the monomeric and total sMD-2 content in plasma increased with the kinetics of an acute phase protein. This parallels enhanced TLR4 costimulatory activity. In vitro studies revealed that sMD-2 release appears to be restricted to endothelial and dendritic cells.Synonyms: ESOP-1, ESOP1, LY96, Lymphocyte antigen 96, MD2
- UniProt
- Q9Y6Y9
- 途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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