MVP 抗体
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- 抗原 See all MVP 抗体
- MVP (Major Vault Protein (MVP))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This MVP antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 特异性
- This Monoclonal antibody clone 1011 is specific for a 104- kDa protein. This mAb is one of four mAb which recognize different epitopes of the protein. Cells whose supernatant showed a positive signal for a 104- kDa band were selected and cloned by limited dilution.
- 交叉反应 （详细）
- Species reactivity (tested):Human.
- 纯化方法
- Purified
- 免疫原
- A BALB/c mouse was immunized with 5 myg of affinity purified nuclear extract proteins. Spleen cells were fused with equal number of Sp0Ag-14 myeloma cells.
- 克隆位点
- 1011
- 亚型
- IgG1
- Top Product
- Discover our top product MVP Primary Antibody
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anti-Major Vault Protein (MVP) (AA 1-893) antibody
MVP 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2H3-1A6 unconjugated
anti-Major Vault Protein (MVP) antibodyMVP 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Major Vault Protein (MVP) (AA 2-272) antibodyMVP 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Major Vault Protein (MVP) (C-Term) antibodyMVP 适用: 人 WB, FACS, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Major Vault Protein (MVP) antibodyKO Validated MVP 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Major Vault Protein (MVP) (AA 2-259) antibodyMVP 适用: 人, 小鼠, 大鼠 WB, IHC, FACS, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-Major Vault Protein (MVP) antibodyMVP 适用: 人, 小鼠, 大鼠 WB, FACS, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Major Vault Protein (MVP) (AA 88-180) antibodyMVP 适用: 人, 斑马鱼 FACS, ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Major Vault Protein (MVP) antibodyMVP 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Major Vault Protein (MVP) antibodyMVP 适用: 人 FACS, IF 宿主: 小鼠 Monoclonal 1014 unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.1 mg/mL
- 缓冲液
- PBS, 0.05 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- MVP (Major Vault Protein (MVP))
- 别名
- Major Vault Protein (MVP 产品)
- 背景
- MVP is identical to lung-resistance related protein (LRP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70 % of their mass. Their shape is reminiscent of the nucleopore central plug. Amino acid 241-280 of human estrogen receptor (ER), (site of nuclear localization signal sequence), is mapped to be the site of interaction between ER and MVP. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. Anti-estrogen 1C1182 shows no effect. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to progesterone and glucocorticoid receptors are also able to co-immunoprecipitate the MVP. LRP is a protein overexpressed in many neoplastic tissues and cell lines. Expression of LRP predicts a poor response to chemotherapy.This 104-kD protein is the major vault protein (MVP) also described as the lung resistance protein (LRP) and has shown to interact with the estrogen receptor. The protein is part of a very large vault ribonucleoprotein complex present in all eukaryotic cells and its structure and protein composition is highly conserved. Because of the size, shape, and protein and RNA composition of this complex the particles are different from other ribonucleoproteins.Synonyms: LRP, Lung-Resistance Related Protein, MVP
- 基因ID
- 9961
- NCBI登录号
- NP_005106
- UniProt
- Q14764
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