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IL1RN 抗体

IL1RN 适用: 人 WB, EIA, IHC (fro) 宿主: 小鼠 Monoclonal 2D11 unconjugated
产品编号 ABIN1107737
发货至: 中国
  • 抗原 See all IL1RN 抗体
    IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))
    适用
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    宿主
    • 96
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    小鼠
    克隆类型
    • 103
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    单克隆
    标记
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    This IL1RN antibody is un-conjugated
    应用范围
    • 115
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    Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    The antibody reacts specificly with Human IL-1ra3. Other species not tested.
    纯化方法
    Protein G
    克隆位点
    2D11
    亚型
    IgG1
    Top Product
    Discover our top product IL1RN Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.1 mg/mL
    缓冲液
    PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store at 2 - 8 °C.
  • 抗原
    IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))
    别名
    IL1RN / IL1RA (IL1RN 产品)
    别名
    DIRA antibody, ICIL-1RA antibody, IL-1RN antibody, IL-1ra antibody, IL-1ra3 antibody, IL1F3 antibody, IL1RA antibody, IRAP antibody, MVCD4 antibody, IRAP1 antibody, IL1RN antibody, IL-1RA antibody, F630041P17Rik antibody, interleukin 1 receptor antagonist antibody, interleukin 1 receptor antagonist-like antibody, IL1RN antibody, Il1rn antibody, IL1RNL antibody
    背景
    IL-1ra3 belongs to the IL-1 system which includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1 R I and IL-1 R II) and the IL-1 receptor accessory protein. Three molecular isoforms of the IL-1 receptor antagonist (IL-1ra) have been identified and cloned. Secreted IL-1ra (sIL-1ra or IL-1ra1) contains a classical leader peptide giving a released mature protein. Two intracellular isoforms, icIL-1ra type I (IL-1ra2) and icIL-1 ra type II (IL-1ra3), have no leader sequence, thus predicting that these proteins remain intracellular. IL-1ra3 may represent a reservoir of IL-1 inhibitors, released upon cell death, whose function is to limit the pro-inflammatory action of cell debris. Studies have shown that IL-1ra3 is expressed by various cell types upon exposure to inflammatory signals but most prominently by mononuclear phagocytes and keratinocytes.Synonyms: ICIL-1RA, IL-1RN, IL-1ra, IL1 inhibitor, IL1F3, IRAP, Interleukin-1 receptor antagonist protein
    基因ID
    3557
    NCBI登录号
    NP_000568
    UniProt
    P18510
    途径
    NF-kappaB Signaling, Hormone Transport, Cancer Immune Checkpoints
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