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IL1RL1 抗体 (Interleukin 1 Receptor-Like 1) (PE)

Details for Product anti-IL1RL1 Antibody No. ABIN1107733, 供应商: Log in to see
抗原
  • DER4
  • Fit-1
  • Ly84
  • ST2L
  • St2
  • St2-rs1
  • T1
  • T1/ST2
  • FIT-1
  • IL33R
  • ST2
  • ST2V
  • FIT1
  • interleukin 1 receptor-like 1
  • Il1rl1
  • IL1RL1
适用

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宿主
小鼠
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6
克隆类型 (克隆位点)
单克隆 ()
标记
This IL1RL1 antibody is conjugated to PE
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应用范围
Flow Cytometry (FACS)
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36
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13
6
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2
1
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Supplier
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免疫原 Secreted form of ST2 protein which were purified from culture supernatant of COS7 transfectant cells
克隆位点 2A5
亚型 IgG1
特异性 This antibody reacts with ST2.
交叉反应 (详细) Species reactivity (tested):Human
纯化方法 Protein A agarose
别名 IL1RL1 / ST2 (IL1RL1 Antibody 摘要)
背景 The ST2 gene, also known as T1, Fit1, or DER4, was originally identified as a responsive gene that was highly induced by stimulation of various proliferation-inducing agents including serum, PDGF (platelet-derived growth factor), FGF (fibroblast growth factor), or lysophosphatidic acid in murine fibroblasts. Three distinct forms of gene products have been reported and named ST2, ST2V, and ST2L. ST2 is a soluble secreted form of 37 kDa protein, which lacks intracellular domain, whereas ST2L is a transmembrane form of 62 kDa protein (the glycosylated forms of ST2 and ST2L are about 57 and 80 kDa, respectively). This ST2L protein is very similar to IL-1R (interleukin-1 receptor) type I and II in structure, thus it is considered as a member of the IL-1R family. ST2V, which is another novel variant form of human ST2, has been identified recently. ST2 proteins are expressed in the wide variety types of human cells, including hematopoietic cells in various stages of differentiation, a population of the peripheral blood mononuclear cells from healthy individuals, glioblastoma and astrocytoma cell lines, and colon cancer cells in addition to fibroblast cell lines. Thus ST2 proteins are considered to have some roles in regulating cell growth or proliferation. On the other hand, either definitive functions of ST2 proteins or their ligand molecule(s) which binds to ST2 proteins have remained unclear, though it has been reported that none of IL-1a, ß, RA (receptor antagonist) binds to ST2 proteins in spite of their structural similarity to IL-1R. This indicates that ST2L protein is functionally independent from IL-1R. Furthermore, several studies have shown that ST2L is expressed on the cell surface of Th2 cells but not on the Th1 cells, indicating the possibility that ST2L protein participates not only in the regulation of cell growth or proliferation, but also in the immune system including differentiation of T cells or immunological response via helper T cells. From these observations, ST2 proteins are considered to be one of the important proteins participate in various physiological phenomenon, thus further analysis are required to understand its physiological functions.Synonyms: DER4, FIT-1, Homolog of mouse growth stimulation-expressed, Interleukin-1 receptor-like 1, MGC32623
基因ID 9173
NCBI登录号 NP_003847
UniProt Q01638
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
状态 Liquid
缓冲液 50 tests in 1 mL volume of PBS, 0.09 % NaN3, 1 % BSA
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C
储存方法 Store at 2 - 8 °C.
厂商提供的图像
Flow Cytometry (FACS) image for anti-IL1RL1 抗体 (Interleukin 1 Receptor-Like 1)  (PE) (ABIN1107733) anti-Interleukin 1 Receptor-Like 1 (IL1RL1) antibody (PE)
背景 Shimizu, Matsuda, Yanagisawa, Hirota, Akahoshi, Inomata, Ebe, Tanaka, Sugiura, Nakashima, Tamari, Takahashi, Obara, Enomoto, Okayama, Gao, Huang, Tominaga, Ikezawa, Shirakawa: "Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis." in: Human molecular genetics, Vol. 14, Issue 19, pp. 2919-27, 2005 (PubMed).

Tajima, Oshikawa, Tominaga, Sugiyama: "The increase in serum soluble ST2 protein upon acute exacerbation of idiopathic pulmonary fibrosis." in: Chest, Vol. 124, Issue 4, pp. 1206-14, 2003 (PubMed).

Haga, Yanagisawa, Ohto-Ozaki, Tominaga, Masuzawa, Iwahana: "The effect of ST2 gene product on anchorage-independent growth of a glioblastoma cell line, T98G." in: European journal of biochemistry / FEBS, Vol. 270, Issue 1, pp. 163-70, 2002 (PubMed).

Burman, Jones: "Treatment of HIV-related tuberculosis in the era of effective antiretroviral therapy." in: American journal of respiratory and critical care medicine, Vol. 164, Issue 1, pp. 7-12, 2001 (PubMed).

Kuroiwa, Li, Tago, Iwahana, Yanagisawa, Komatsu, Oshikawa, Sugiyama, Arai, Tominaga: "Construction of ELISA system to quantify human ST2 protein in sera of patients." in: Hybridoma, Vol. 19, Issue 2, pp. 151-9, 2000 (PubMed).

Tominaga, Kuroiwa, Tago, Iwahana, Yanagisawa, Komatsu: "Presence and expression of a novel variant form of ST2 gene product in human leukemic cell line UT-7/GM." in: Biochemical and biophysical research communications, Vol. 264, Issue 1, pp. 14-8, 1999 (PubMed).

Ikeda, Wachi, Seyama, Tajima: "Effects of monensin on tropoelastin metabolism in vascular smooth muscle cells: monensin causes intracellular degradation of accumulated tropoelastin." in: Journal of biochemistry, Vol. 121, Issue 1, pp. 5-7, 1997 (PubMed).

Yanagisawa, Takagi, Tsukamoto, Tetsuka, Tominaga: "Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1." in: FEBS letters, Vol. 318, Issue 1, pp. 83-7, 1993 (PubMed).

Lanahan, Williams, Sanders, Nathans: "Growth factor-induced delayed early response genes." in: Molecular and cellular biology, Vol. 12, Issue 9, pp. 3919-29, 1992 (PubMed).

Rospendowski, Farrens, Cotton, Song: "Surface enhanced resonance Raman scattering (SERRS) as a probe of the structural differences between the Pr and Pfr forms of phytochrome." in: FEBS letters, Vol. 258, Issue 1, pp. 1-4, 1990 (PubMed).