Species reactivity (expected):Guinea Pig, Rabbit, Porcine, Bovine, Sheep. Species reactivity (tested):Human.
纯化方法
Protein A chromatography
免疫原
Synthetic peptide corresponding to the amino acids 45-91 of the native molecule conjugated to Bovine Serum Albumin. N-terminal fragment of human MBP (residues 1-118) produced by BNPS-skatole cleavage of pure Human MBP, injected coupled to BSA using carbodiimide.
ELISA. Radioimmunoassays. Immunohistochemistry on Paraffin Sections (10 μg/mL). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
C76307 antibody, Hmbpr antibody, R75289 antibody, golli-mbp antibody, mld antibody, shi antibody, Mbps antibody, cb274 antibody, fj33b11 antibody, mbp antibody, wu:fj33b11 antibody, wu:fq15b02 antibody, zgc:136630 antibody, MGC115135 antibody, myelin basic protein antibody, myelin basic protein a antibody, myelin basic protein L homeolog antibody, MBP antibody, Mbp antibody, mbpa antibody, mbp antibody, mbp.L antibody
背景
The classic group of Myelin basic protein (MBP) isoforms (isoforms 4 to 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non classic group of MBP isoforms (isoforms 1 to 3/Golli MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.Synonyms: MBP, Myelin membrane encephalitogenic protein