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CD45 抗体 (FITC)

PTPRC 适用: 人 FACS, IF 宿主: 小鼠 Monoclonal MT2 FITC
产品编号 ABIN1106413
发货至: 中国
  • 抗原 See all CD45 (PTPRC) 抗体
    CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))
    适用
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    宿主
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    小鼠
    克隆类型
    • 467
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    单克隆
    标记
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    This CD45 antibody is conjugated to FITC
    应用范围
    • 503
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    Flow Cytometry (FACS), Immunofluorescence (IF)
    特异性
    Clone MT2, specific for CD45RC, reacts with with a 95-115 kDa highly sialated glycoprotein. Clone MT2 has previously been described as CD45RA but due to its reactivity with transfectants and its identical staining pattern with ORTH75E4 it is now recognized as CD45RC [7]. Clone MT2 reacts with peripheral blood B cells and is used for the differential diagnosis of non-Hodgkin lymphomas. It also reacts with T suppressor/cytotoxic cells and NK cells. Other isoforms can be detected using anti-CD45RA (clone MB1, cat.no. AM39020), or anti-CD45RB (clone MT4, cat.no. AM39021).
    纯化方法
    Affinity chromatography
    克隆位点
    MT2
    亚型
    IgG1
    Top Product
    Discover our top product PTPRC Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 缓冲液
    0.01 M Sodium Phosphate, 0.15 M NaCl, pH 7.3, 0.09 % Sodium Azide, 0.2 % BSA
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.
  • 抗原
    CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))
    别名
    CD45 / LCA (PTPRC 产品)
    别名
    PTPRC antibody, si:dkeyp-47c5.1 antibody, B220 antibody, CD45 antibody, CD45R antibody, GP180 antibody, L-CA antibody, LCA antibody, LY5 antibody, T200 antibody, Cd45 antibody, Ly-5 antibody, Lyt-4 antibody, loc antibody, Lca antibody, RT7 antibody, cd45 antibody, protein tyrosine phosphatase, receptor type C antibody, protein tyrosine phosphatase, receptor type, C antibody, receptor-type tyrosine-protein phosphatase C antibody, PTPRC antibody, ptprc antibody, LOC100074271 antibody, Ptprc antibody
    背景
    The CD45 Molecule is also known as the Leukocyte Common Antigen (LCA) or T200 antigen, and is comprised of different glycoproteins ranging from 180-240 kD [1,2]. CD45 is a family of transmembrane protein tyrosine phosphatases critically involved in the regulation of lymphocyte activation signals. Expression of CD45 is found on all hemopoietic cells, e.g. granulocytes, monocytes, macrophages and lymphocytes, except mature erythroid cells. In humans, there is heterogeneous expression of CD45 isoforms (RA, RB, RO, RC) on lymphocyte subpopulations. Detection of the different isoforms can distinguish, for example, between naive T cells and memory T cells, which is of interest in patients with immunodeficiency and autoimmune diseases.Synonyms: L-CA, Leukocyte common antigen, PTPRC, Receptor-type tyrosine-protein phosphatase C, T200
    基因ID
    5788
    NCBI登录号
    NP_002829
    UniProt
    P08575
    途径
    TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, BCR Signaling
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