TLR3 抗体 (FITC)
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- 抗原 See all TLR3 抗体
- TLR3 (Toll-Like Receptor 3 (TLR3))
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适用
- 人, 小鼠, 犬
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This TLR3 antibody is conjugated to FITC
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)
- 特异性
- The monoclonal antibody TLR3.7 recognizes the 116 kDa human Toll-like receptor 3 (TLR3, CD283).
- 交叉反应 （详细）
- Species reactivity (tested):Human, mouse, canine
- 纯化方法
- Protein G
- 免疫原
- Human Flag-tagged TLR3 stably expressed by Ba/F3 cells
- 克隆位点
- TLR3-7
- 亚型
- IgG1
- Top Product
- Discover our top product TLR3 Primary Antibody
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anti-Toll-Like Receptor 3 (TLR3) (AA 404-532) antibody
TLR3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 3 (TLR3) (AA 464-647) antibodyTLR3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 3 (TLR3) (AA 801-905) antibodyTLR3 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 3 (TLR3) (AA 55-85) antibodyTLR3 适用: 人 WB, FACS, IP, ICC, IF, IHC (p) 宿主: 小鼠 Monoclonal 40C1285-6 unconjugated
anti-Toll-Like Receptor 3 (TLR3) (AA 24-217) antibodyTLR3 适用: 人 WB, IHC, ELISA, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 6F3G4 unconjugated
anti-Toll-Like Receptor 3 (TLR3) (C-Term) antibodyTLR3 适用: 人 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 3 (TLR3) (AA 135-297) antibodyTLR3 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 3 (TLR3) antibodyTLR3 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 3 (TLR3) (AA 55-70) antibodyTLR3 适用: 人, 猴, 山羊, 绵羊 WB, IHC, FACS, IP, IHC (p) 宿主: 小鼠 Monoclonal 40C1285-6 unconjugated
anti-Toll-Like Receptor 3 (TLR3) (C-Term) antibodyTLR3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.1 mg/mL
- 缓冲液
- PBS, 0.02 % sodium azide, 1 % bovine serum albumin
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store at 2 - 8 °C.
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- 抗原
- TLR3 (Toll-Like Receptor 3 (TLR3))
- 别名
- CD283 / TLR3 (TLR3 产品)
- 别名
- CD283 antibody, IIAE2 antibody, AI957183 antibody, zgc:123006 antibody, toll like receptor 3 antibody, toll-like receptor 3 antibody, TLR3 antibody, Tlr3 antibody, tlr3 antibody
- 背景
- Toll-like receptors (TLRs) are highly conserved from Drosophila to humans and share structural and functional similarities. TLRs constitute of a family of pattern recognition receptors (PRRs) that mediate cellular responses to a large variety of pathogens (viruses, bacteria, and parasites) by specific recognition of so-called 'pathogen-associated molecular patterns'. Activation of TLRs, a family of at least 11 different members that function either as homo- or heterodimers, leads to activation of NFκB-dependent and IFN-regulatory factor-dependent signaling pathways. TLRs have a central role in innate immunity and are also required for the development of an adaptive immune response. TLRs are expressed by various cells of the immune system, such as macrophages and dendritic cells. TLRs are class I receptors, with a single α-helix that spans the cell membrane. They recognize and respond to molecules derived from bacterial, viral and fungal pathogens, such as lipopolysaccharide (LPS) from the outer membrane of Gram negative bacteria, peptidoglycan fragments from bacterial cell walls and single-stranded and double-stranded RNA from viruses. Some forms of RNA and DNA from pathogens exhibit immutable features that distinguish them from nucleic acids of higher organisms. For example, dsRNA, is a common intermediate of viral replication and a potent indicator of infection. Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA and its synthetic analog polyriboinosinic:polyribocytidylic acid (poly(I:C)). TLR3 is normally located in acidic endosomes where its luminal ectodomain (ECD) encounters dsRNA and induces type I interferon (IFN), inflammatory cytokine/chemokine production and dendritic cell (DC) maturation via the adaptor protein TICAM-1 (also called TRIF). Based on the different subcellular localization of cytosolic RNA receptors and TLR3, these receptors seem to play distinct roles in anti-viral immune responses.Synonyms: Toll-like receptor 3
- 基因ID
- 7098
- NCBI登录号
- NP_003256
- UniProt
- O15455
- 途径
- TLR signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades
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