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HAS2 抗体 (AA 67-170)

HAS2 适用: 人 ELISA, WB, IHC, ICC 宿主: 小鼠 Monoclonal 4-00E-07 unconjugated
产品编号 ABIN1098124
发货至: 中国
  • 抗原 See all HAS2 抗体
    HAS2 (Hyaluronan Synthase 2 (HAS2))
    抗原表位
    • 9
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 67-170
    适用
    • 41
    • 24
    • 14
    宿主
    • 38
    • 12
    小鼠
    克隆类型
    • 38
    • 12
    单克隆
    标记
    • 15
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HAS2 antibody is un-conjugated
    应用范围
    • 30
    • 20
    • 12
    • 11
    • 8
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    纯化方法
    purified
    免疫原
    Purified recombinant fragment of human HAS2 (AA: 67-170) expressed in E. coli.
    克隆位点
    4-00E-07
    亚型
    IgG1
  • 应用备注
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:100 - 1:500
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified antibody in PBS with 0.05 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    4°C, -20°C for long term storage
  • Okuda, Kobayashi, Xia, Watabe, Pai, Hirota, Xing, Liu, Pandey, Fukuda, Modur, Ghosh, Wilber, Watabe: "Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells." in: Cancer research, Vol. 72, Issue 2, pp. 537-47, (2012) (PubMed).

    Jokela, Makkonen, Oikari, Kärnä, Koli, Hart, Tammi, Carlberg, Tammi: "Cellular content of UDP-N-acetylhexosamines controls hyaluronan synthase 2 expression and correlates with O-linked N-acetylglucosamine modification of transcription factors YY1 and SP1." in: The Journal of biological chemistry, Vol. 286, Issue 38, pp. 33632-40, (2011) (PubMed).

  • 抗原
    HAS2 (Hyaluronan Synthase 2 (HAS2))
    别名
    HAS2 (HAS2 产品)
    别名
    DG42 antibody, XHas2 antibody, Has2 antibody, hyaluronan synthase 2 antibody, hyaluronan synthase 2 S homeolog antibody, has2 antibody, HAS2 antibody, Has2 antibody, SHAS2 antibody, has2.S antibody
    背景
    Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.
    分子量
    63.5 kDa
    基因ID
    3037
    HGNC
    3037
    途径
    Glycosaminoglycan Metabolic Process
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