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Glycogen Synthase 1 抗体 (pSer640)

GYS1 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1043895
发货至: 中国
  • 抗原 See all Glycogen Synthase 1 (GYS1) 抗体
    Glycogen Synthase 1 (GYS1) (Glycogen Synthase 1 (Muscle) (GYS1))
    抗原表位
    • 15
    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer640
    适用
    • 59
    • 35
    • 29
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    宿主
    • 59
    • 1
    克隆类型
    • 46
    • 14
    多克隆
    标记
    • 39
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    This Glycogen Synthase 1 antibody is un-conjugated
    应用范围
    • 39
    • 26
    • 13
    • 10
    • 9
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
    特异性
    This affinity purified antibody is directed against human muscle glycogen synthase. The product was affinity purified from monospecific antiserum by immunoaffinity purification. Antiserum was first purified against the phosphorylated form of the immunizing peptide. The resultant affinity purified antibody was then cross-adsorbed against the non-phosphorylated form of the immunizing peptide. This phospho specific polyclonal antibody is specific for phosphorylated pS640 of human muscle glycogen synthase. Reactivity with non-phosphorylated human muscle glycogen synthase is less than 1% by ELISA. Cross reactivity with muscle glycogen synthase occurs in mouse tissue. Reactivity with muscle glycogen synthase from other sources has not been determined.
    产品特性
    Human muscle glycogen synthase (GS) is responsible for the biosynthesis of glycogen from phosphorylated glucose units. Mammalian liver and muscle contain GS consisting of four subunits with a total molecular weight of 360,000. GS is subject to regulation through both allosteric and covalent modification and occurs in two forms: the phosphorylated inactive form, and the dephos-phorylated active form. GS is inactivated by the serine/threonine kinase called glycogen synthase kinase-3β that mainly functions to phos-phorylate muscle glycogen synthase. This antibody is specific for the phosphorylated form of GS at S640. Phosphorylation of GS at S640 has been associated with Antiphospholipid Antibody Syndrome.
    过滤
    Sterile filtered
    免疫原
    Human Muscle Glycogen Synthase phospho peptide corresponding to a region of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
    Immunogen Type: Peptide
    亚型
    IgG
    Top Product
    Discover our top product GYS1 Primary Antibody
  • 应用备注
    This phospho specific polyclonal antibody was tested by immunoblotting and ELISA. By ELISA the antibody was found to be reactive with the phosphorylated form of the immunizing peptide and minimally reactive with the non-phosphorylated form of the immunizing peptide. Immunoblotting will detect human and mouse muscle glycogen synthase. Although not tested, this antibody is likely functional in immunohistochemistry and immunoprecipitation.
    说明

    Gene Name: GYS1

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.0 mg/mL
    缓冲液
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    储存液
    Without preservative
    储存条件
    4 °C/-20 °C
    储存方法
    Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
    有效期
    12 months
  • Kelsall, Voss, Munro, Cuthbertson, Cohen: "R3F, a novel membrane-associated glycogen targeting subunit of protein phosphatase 1 regulates glycogen synthase in astrocytoma cells in response to glucose and extracellular signals." in: Journal of neurochemistry, Vol. 118, Issue 4, pp. 596-610, (2011) (PubMed).

  • 抗原
    Glycogen Synthase 1 (GYS1) (Glycogen Synthase 1 (Muscle) (GYS1))
    别名
    Muscle Glycogen Synthase (GYS1 产品)
    别名
    GSY antibody, GYS antibody, GYS1 antibody, zgc:63701 antibody, GYS2 antibody, Gys3 antibody, MGS antibody, glycogen synthase 1 antibody, glycogen synthase 1 (muscle) antibody, glycogen synthase 1, muscle antibody, GYS1 antibody, gys1 antibody, Gys1 antibody
    背景
    Anti-Glycogen Synthase 1 pS640 antibody is validated by IHC, Western Blot and ELISA. Human muscle glycogen synthase (GS) is responsible for the biosynthesis of glycogen from phosphorylated glucose units. Mammalian liver and muscle contain GS consisting of four subunits with a total molecular weight of 360,000. GS is subject to regulation through both allosteric and covalent modification and occurs in two forms: the phosphorylated inactive form, and the dephos-phorylated active form. GS is inactivated by the serine/threonine kinase called glycogen synthase kinase-3β that mainly functions to phos-phorylate muscle glycogen synthase. This antibody is specific for the phosphorylated form of GS at S640. Phosphorylation of GS at S640 has been associated with Antiphospholipid Antibody Syndrome.
    Synonyms: Glycogen antibody, Glycogen synthase 1 (muscle) antibody, Glycogen synthase 1 antibody, Glycogen synthase1 antibody, GSY antibody, GYS 1 antibody, GYS antibody, GYS1 antibody, Starchsynthase muscle antibody
    基因ID
    2997
    UniProt
    P13807
    途径
    PI3K-Akt Signaling, AMPK Signaling, Cellular Glucan Metabolic Process
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