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抗Mouse (Murine) PRKACB 抗体:
抗Rat (Rattus) PRKACB 抗体:
抗Human PRKACB 抗体:
Gli2 (显示 GLI2 抗体) and Gli3 (显示 GLI3 抗体) are dephosphorylated and activated in cilia and that impaired Gli2 (显示 GLI2 抗体) and Gli3 (显示 GLI3 抗体) processing in Ta3 (显示 HSP90B1 抗体) mutant is at least in part due to a decrease in Gli2 (显示 GLI2 抗体) and Gli3 (显示 GLI3 抗体) phosphorylation.
Data indicate that TRPV4 activity and TRPV4 trafficking are under discrete but synergistic control of PKC- and PKA-dependent pathways.
Studies identified three novel alternatively spliced transcript variants of the mouse protein kinase A catalytic beta subunit (显示 POLG 抗体) (Cbeta) gene designated Cbeta5, Cbeta6 and Cbeta7.
These data suggest that both developmental and tumor phenotypes caused by Prkar1a (显示 PRKAR1A 抗体) mutation result from excess PKA activity due to PKA-Ca.
crystal structure of the catalytic subunit in complex with ADP, aluminum fluoride, Mg2 (显示 MCOLN1 抗体)+ ions and a substrate peptide was determined at 2.0 A resolution
glucose and glucagon (显示 GCG 抗体)-like polypeptide-1 (显示 CYP 抗体) caused translocation of Calpha (显示 PRKACA 抗体) to the nucleus and of Cbeta to the plasma membrane and the nucleus, but did not affect the distribution of Cgamma in pancreatic beta-cells
Murine lymphoid tissues express a protein that is a homologue of human and bovine Cbeta2
Protein kinase A, C beta subunit (显示 POLG 抗体) is not essential for neuronal development or function but may play a more subtle role in memory that is modulated by strain-specific genetic modifiers.
analysis of the mechanism underlying synergistic up-regulation of PDE4B2 via a cross-talk between PKA-Cbeta and p65 (显示 GORASP1 抗体)
The gene polymorphism loci rs12132032 in PRKACB maybe a potential risk factor for anencephaly in Chinese population from Shanxi, while gender susceptibility may influence the correlation.
The previously unknown small molecule inhibitor-dependent interaction of Cbeta1 with the cell cycle and apoptosis regulatory protein-1 (显示 CCAR1 抗体) was verified.
PGE (显示 LIPF 抗体)(2)-induced CYP1B1 (显示 CYP1B1 抗体) expression is mediated by ligand-independent activation of the ERalpha (显示 ESR1 抗体) pathway as a result of the activation of ERK (显示 EPHB2 抗体), Akt (显示 AKT1 抗体), and PKA in breast cancer cells.
Data show that PI3K activation and PIP3 production lead to recruitment of the PKB/beta-arrestin/PDE4 complex to the membrane via the PKB PH domain, resulting in degradation of the TCR-induced cAMP pool and allowing full T-cell activation to proceed.
Results suggest that PKA can negatively regulate ERalpha (显示 ESR1 抗体), at least in part, through FoxH1 (显示 FOXH1 抗体).
c-MYC (显示 MYC 抗体) induces the activity of protein kinase A by inducing the transcription of the gene encoding the PKA catalytic subunit beta in multiple tissues, independent of cell proliferation by direct binding of c-MYC (显示 MYC 抗体) to promoter sequences.
Data describe the identification of a variant of the beta catalytic subunit of cyclic AMP (显示 APRT 抗体)-dependent protein kinase (显示 CDK7 抗体) (PKACbeta) as a p75 neurotrophin receptor (显示 NGFR 抗体)(NTR)-interacting protein, which phosphorylates p75(NTR (显示 NGFR 抗体)) at Ser304.
there are abnormalities in [3H]cAMP binding and catalytic activity kinase A in brain of depressed suicide victims, which could be due to reduced expression of RIIbeta (显示 PRKAR2B 抗体) and Cbeta.
there is a PKA-Cbeta-mediated inhibitory mechanism of p73 (显示 TP73 抗体) function
Murine lymphoid tissues express a protein that is a homolog of bovine Cbeta2 (protein kinase c subunit beta2).
critically involved in mediating the phosphorylation of AMP (显示 TMPRSS5 抗体) kinase promoted by hydrogen peroxide in endothelial cells.
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed.
p70 S6 kinase
, protein kinase, cAMP-dependent, catalytic, beta a
, protein kinase, cAMP-dependent, catalytic, beta
, cAMP-dependent protein kinase catalytic subunit beta
, PKA C-beta
, cAMP-dependent protein kinase C beta
, cAMP-dependent protein kinase catalytic beta subunit isoform 4ab
, protein kinase A catalytic subunit beta
, C-beta subunit