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AMPK activation inhibited IL-1beta (显示 IL1B ELISA试剂盒)-stimulated CXCL10 (显示 CXCL10 ELISA试剂盒) secretion, associated with reduced interleukin-1 receptor associated kinase-4 (IRAK4 (显示 IRAK4 ELISA试剂盒)) phosphorylation.
Findings indicate that the energy-sensing LKB1 (显示 STK11 ELISA试剂盒)-AMPK pathway regulates IGF1 (显示 IGF1 ELISA试剂盒) secretion in mouse primary hepatocytes, which in turn regulates activation of the IGF1R (显示 IGF1R ELISA试剂盒)-PKB (显示 AKT2 ELISA试剂盒) pathway.
These data suggest that nutrient availability dictates the mode of division and that LKB1 (显示 STK11 ELISA试剂盒)-AMPK mediates this nutrient-driven effect on intestinal epithelial stem cell proliferation.
Myeloid-Restricted AMPKalpha1 Promotes Host Immunity and Protects against IL-12 (显示 IL12A ELISA试剂盒)/23p40-Dependent Lung Injury during Hookworm Infection
Data suggest that Il4 (显示 IL4 ELISA试剂盒) (usually released from helper T-cells) induces Cox1 (显示 COX1 ELISA试剂盒) in macrophages at post-transcriptional level; activation of Ampk (catalytic subunit Prkaa1) by metformin blocks Il4 (显示 IL4 ELISA试剂盒)-dependent induction of Cox1 (显示 COX1 ELISA试剂盒) and blocks macrophage polarization/activation. (Il4 (显示 IL4 ELISA试剂盒) = interleukin-4 (显示 IL4 ELISA试剂盒); Cox1 (显示 COX1 ELISA试剂盒) = cyclooxygenase 1 (显示 PTGS1 ELISA试剂盒); Ampk = AMP-activated protein kinase (显示 PRKAA2 ELISA试剂盒))
The metformin-rescued P23H rhodopsin (显示 RHO ELISA试剂盒) was still intrinsically unstable and led to increased structural instability of the rod outer segments. These data suggest that improving the traffic of misfolding rhodopsin (显示 RHO ELISA试剂盒) mutants is unlikely to be a practical therapy, but also highlights the potential of altering translation through AMPK to improve protein function in other protein misfolding diseases
Mechanistically, miR (显示 MLXIP ELISA试剂盒)-499 directly targets Fnip1 (显示 FNIP1 ELISA试剂盒), an AMP-activated protein kinase (AMPK (显示 PRKAA2 ELISA试剂盒))-interacting protein that negatively regulates AMPK, a known activator of PGC-1alpha (显示 PPARGC1A ELISA试剂盒). This miR (显示 MLXIP ELISA试剂盒)-499/Fnip1 (显示 FNIP1 ELISA试剂盒)/AMPK circuit can serve as a mechanism to couple muscle fiber type and mitochondrial function.
dopamine is coupled to AMPK activation, which provides a substantial anti-inflammatory and bioenergetic advantage and reduces the severity of endotoxin-induced acute lung injury.
AMPKalpha1 deficiency suppresses brown adipogenesis in favor of fibrogenesis during brown adipose tissue development.
mitochondrial dysfunction triggers LKB1 (显示 STK11 ELISA试剂盒)-mediated AMPK activation, which stimulates Sirt2 (显示 SIRT2 ELISA试剂盒) phosphorylation, leading to activation of mTOR (显示 FRAP1 ELISA试剂盒)-RAPTOR (显示 RPTOR ELISA试剂盒) and Glut1 (显示 SLC2A1 ELISA试剂盒)-mediated glucose uptake.
Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK (显示 PRKAA2 ELISA试剂盒)).
The results suggest that activation of AMPK represses global protein synthesis in mammary epithelial cells through inhibition of mTORC1 signaling.
Nitrated oleic acid activates AMPK in endothelial cells.
Findings suggest that ischemic factor stimulation of the blood brain barrier Na-K-Cl cotransporter (显示 SLC12A1 ELISA试剂盒) involves activation of AMPK.
Results suggest that mitochondria-derived superoxide anions and peroxynitrite are required for Berberine-induced AMPK activation in endothelial cells.
the expression, but not the kinase activity, of AMPK and CaMKKbeta is necessary for ADP signaling to eNOS (显示 NOS3 ELISA试剂盒)
Our results indicated that H. pylori infection, CagA (显示 S100A8 ELISA试剂盒) status, and PRKAA1 polymorphisms were risk factors for gastric cancer in Koreans, and that the combination of two of these factors rather than their independent effects synergistically increased the risk.
Taken together, these data indicated that adiponectin promotes endothelial progenitor cell proliferation and migration via AMPK/Akt/eNOS signaling pathway and promotes tube formation through AMPK/eNOS, suggesting that adiponectin-transduced endothelial progenitor cell transplantation is a potential therapeutic target for vascular disease.
We will also describe distinct crossroads between the regulation of longevity and cancer, e.g. specific regulation through the AMPKalpha (显示 GRK4 ELISA试剂盒) and HIF-alpha isoforms, the Warburg effect, mitochondrial dynamics, and cellular senescence. [review]
These results suggest that the LKB1 (显示 STK11 ELISA试剂盒)-AMPK-FoxO1 (显示 FOXO1 ELISA试剂盒) signaling pathway is a critical mediator of the antioxidant properties of H2, further supporting the idea that H2 acts as a signaling molecule to serve various physiological functions.
this study shows taht AMPK reduces abnormal inflammatory responses and cellular senescence, which implicates as a potential therapeutic target for chronic obstructive pulmonary disease/emphysema
Salusin-beta mediates high glucose-induced endothelial injury via disruption of AMPK signaling pathway.
These findings identify a key mechanism of tolerance to Ras-Raf (显示 RAF1 ELISA试剂盒) pathway inhibitors and suggest that blocking either AMPK or autophagy in combination with these targeted inhibitors could increase tumor regression and decrease the likelihood of eventual recurrence.
the Runx2 (显示 RUNX2 ELISA试剂盒) knockdown cells displayed activation of AMP-activated protein kinase (AMPKalpha (显示 GRK4 ELISA试剂盒)), the sensor of cellular metabolism. Importantly, the Runx2 (显示 RUNX2 ELISA试剂盒) knockdown in bone-derived cells resulted in increased sensitivity to both Erk1/2 (显示 MAPK1/3 ELISA试剂盒) inhibition and AMPKalpha (显示 GRK4 ELISA试剂盒) activation by PD184161 and metformin, respectively, despite increased IGF-1Rbeta and AMPKalpha (显示 GRK4 ELISA试剂盒) levels.
AMPK-related pathways may be compromised during fluoxetine exposure as a result of increased miRNA abundance.
Constitutively active AMPKgammaR70Q significantly decreases Napi-IIa oocyte cell membrane abundance, an effect not mimicked by catalytically-inactive AMPKalphaK45R.
NDPK-A (显示 NME1 ELISA试剂盒) exists in a functional cellular complex with AMPK (显示 PRKAA2 ELISA试剂盒) and CFTR (显示 CFTR ELISA试剂盒) in airway epithelia, and NDPK-A (显示 NME1 ELISA试剂盒) catalytic function is required for the AMPK (显示 PRKAA2 ELISA试剂盒)-dependent regulation of CFTR (显示 CFTR ELISA试剂盒)
Klotho (显示 KL ELISA试剂盒) gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (显示 GRK4 ELISA试剂盒)-RUNX2 (显示 RUNX2 ELISA试剂盒) pathway.
AMPK-mTOR (显示 FRAP1 ELISA试剂盒)-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.
Data indicate that 17beta-estradiol reduced Sertoli Cell proliferation by inhibiting microRNA miR (显示 MYLIP ELISA试剂盒)-1285 and thus activating AMP-activated protein kinase (AMPK (显示 PRKAA2 ELISA试剂盒)).
L-Glutamine enhances enterocyte growth but did not affect abundances of total or phosphorylated AMPK protein.
AMPK activity plays an important role in the maintenance of the spermatozoa quality during long-term storage of boar semen.
AMPK, lying downstream of PKA, regulates at different levels mammalian spermatozoa membrane function.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK/ERK (显示 MAPK1 ELISA试剂盒)/TSC2 (显示 TSC2 ELISA试剂盒)/mTOR (显示 FRAP1 ELISA试剂盒) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
AMPK deficiency or inhibition attenuated or mitigated ethanol exposure-triggered glucose intolerance and compromised cardiac contraction by increased phosphorylation of AMPK and acetyl-CoA carboxylase as well as autophagosome accumulation.
AMPK functions to inhibit IGF-I (显示 IGF1 ELISA试剂盒)-stimulated PI3K pathway activation through stimulation of IRS-1 (显示 IRS1 ELISA试剂盒) serine 794 phosphorylation.
acute activation of AMPK increases intestinal glucose absorption after administration of long-chain n-3 polyunsaturated fatty acids during gestation
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
5'-AMP-activated protein kinase catalytic subunit alpha-1
, 5'-AMP-activated protein kinase, catalytic alpha-1 chain
, ACACA kinase
, AMP -activate kinase alpha 1 subunit
, AMP-activated protein kinase, catalytic, alpha-1
, AMPK alpha 1
, AMPK subunit alpha-1
, HMGCR kinase
, acetyl-CoA carboxylase kinase
, hydroxymethylglutaryl-CoA reductase kinase
, tau-protein kinase PRKAA1
, 5'-AMP-activated protein kinase alpha-1 catalytic subunit
, 5'-AMP-activated protein kinase alpha 1 catalytic subunit
, 63 kDa subunit
, AMPK 63 kDa subunit
, AMPK alpha-1 chain
, AMP-activated protein kinase, alpha 1 catalytic subunit
, 5'-AMP-activated protein kinase catalyti subunit alpha-1-like protein
, AMPK-activated protein kinase alpha-1 subunit
, protein kinase, AMP-activated, alpha 1 catalytic subunit