anti-PRKAA1 (PRKAA1) 抗体产品概述

Full name:
anti-Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit 抗体 (PRKAA1)
在www.antibodies-online.cn可供318 Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) 抗体的29不同的供货商。 再加上,我们可以发PRKAA1 试剂盒 (20)PRKAA1 蛋白 (8)和数多这个蛋白质的别的产品。 总共355 PRKAA1产品已列进来了。
别名:
AI194361, AI450832, AL024255, AMPK, AMPK1, AMPKa1, AMPKalpha1, C130083N04Rik, cb116, im:7154392, PRKAA1, sb:cb130, wu:fa94c10
列出全部抗体 基因 基因ID UniProt
PRKAA1 108080  
PRKAA1 5562 Q13131
PRKAA1 65248 P54645

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引用最多的anti-PRKAA1 抗体

  1. Cow (Bovine) Polyclonal PRKAA1 Primary Antibody for ICC, IF - ABIN151706 : Zang, Zuccollo, Hou, Nagata, Walsh, Herscovitz, Brecher, Ruderman, Cohen: AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. in The Journal of biological chemistry 2004 (PubMed)
    Show all 12 references for 151706

  2. Human Monoclonal PRKAA1 Primary Antibody for IF, WB - ABIN393792 : Jassim, Fernø, Theisen, Haberhausen, Christoforou, Håvik, Gebhardt, Remschmidt, Mehler-Wex, Hebebrand, Lehellard, Steen: Association study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia. in Pharmacopsychiatry 2011 (PubMed)
    Show all 5 references for 393792

  3. Human Monoclonal PRKAA1 Primary Antibody for ELISA, FACS - ABIN4280435 : Xiao, Kwong, Daemen, Belvin, Liang, Hatzivassiliou, OBrien: Metabolic Response to NAD Depletion across Cell Lines Is Highly Variable. in PLoS ONE 2016 (PubMed)
    Show all 3 references for 4280435

  4. Human Polyclonal PRKAA1 Primary Antibody for IHC (p), WB - ABIN359481 : Pang, Xiong, Li, Qiu, Jin, Shen, Li: Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits. in The Journal of biological chemistry 2007 (PubMed)
    Show all 3 references for 359481

  5. Human Polyclonal PRKAA1 Primary Antibody for IF (p), IHC (p) - ABIN737886 : Fu, Zhu, Dodson, Du: AMP-activated protein kinase stimulates Warburg-like glycolysis and activation of satellite cells during muscle regeneration. in The Journal of biological chemistry 2015 (PubMed)
    Show all 3 references for 737886

  6. Human Polyclonal PRKAA1 Primary Antibody for EIA, WB - ABIN359393 : Zhang, Ye, Wu, Ren, Zhao, Zhao, Fu, Shen, Fan, Lu, Zhong, Xu, Han, Zhang, Tao, Huang, Zhou, Hu, Gu, Chen, Chen: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. in Genome research 2000 (PubMed)
    Show all 2 references for 359393

  7. Cow (Bovine) Polyclonal PRKAA1 Primary Antibody for WB - ABIN2785500 : Hasumi, Baba, Hong, Hasumi, Huang, Yao, Valera, Linehan, Schmidt: Identification and characterization of a novel folliculin-interacting protein FNIP2. in Gene 2008 (PubMed)

  8. Human Polyclonal PRKAA1 Primary Antibody for FACS, IHC (p) - ABIN652306 : Puissant, Robert, Fenouille, Luciano, Cassuto, Raynaud, Auberger: Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation. in Cancer research 2010 (PubMed)

更多抗PRKAA1的相互作用对抗体

Mouse (Murine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. The metformin-rescued P23H rhodopsin (显示 RHO 抗体) was still intrinsically unstable and led to increased structural instability of the rod outer segments. These data suggest that improving the traffic of misfolding rhodopsin (显示 RHO 抗体) mutants is unlikely to be a practical therapy, but also highlights the potential of altering translation through AMPK to improve protein function in other protein misfolding diseases

  2. Mechanistically, miR (显示 MLXIP 抗体)-499 directly targets Fnip1 (显示 FNIP1 抗体), an AMP-activated protein kinase (AMPK (显示 PRKAA2 抗体))-interacting protein that negatively regulates AMPK, a known activator of PGC-1alpha (显示 PPARGC1A 抗体). This miR (显示 MLXIP 抗体)-499/Fnip1 (显示 FNIP1 抗体)/AMPK circuit can serve as a mechanism to couple muscle fiber type and mitochondrial function.

  3. dopamine is coupled to AMPK activation, which provides a substantial anti-inflammatory and bioenergetic advantage and reduces the severity of endotoxin-induced acute lung injury.

  4. AMPKalpha1 deficiency suppresses brown adipogenesis in favor of fibrogenesis during brown adipose tissue development.

  5. mitochondrial dysfunction triggers LKB1 (显示 STK11 抗体)-mediated AMPK activation, which stimulates Sirt2 (显示 SIRT2 抗体) phosphorylation, leading to activation of mTOR (显示 FRAP1 抗体)-RAPTOR (显示 RPTOR 抗体) and Glut1 (显示 SLC2A1 抗体)-mediated glucose uptake.

  6. AMPK-dependent metabolic repair mechanisms are important for mitigating lung injury.

  7. these data demonstrated that LKB1 (显示 STK11 抗体)/AMPK signaling pathway activation improved the survival of diabetic mice complicated with endotoxemia. Thus, LKB1 (显示 STK11 抗体)/AMPK signaling pathway may serve as a potentially useful therapeutic target for severe infection in diabetic patients.

  8. We confirmed that procyanidins suppressed acute hyperglycemia with an oral glucose tolerance test in a dose-dependent manner.procyanidins, especially cinnamtannin A2, significantly ameliorate postprandial hyperglycemia at least in part by promoting GLUT4 (显示 SLC2A4 抗体) translocation to the plasma membrane by activating both insulin (显示 INS 抗体)- and AMPK-signaling pathways.

  9. These findings demonstrate that the AMPK-TBC1D1 (显示 TBC1D1 抗体) signaling nexus interacts with the PKB (显示 AKT2 抗体)-mTOR (显示 FRAP1 抗体) pathway via IGF1 (显示 IGF1 抗体) secretion, which consequently controls expression of lipogenic genes in the adipose tissue

  10. AMPKa1 deficiency impairs autophagy-mediated monocyte differentiation and decreases monocyte/macrophage survival

Cow (Bovine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK (显示 PRKAA2 抗体)).

  2. The results suggest that activation of AMPK represses global protein synthesis in mammary epithelial cells through inhibition of mTORC1 signaling.

  3. Nitrated oleic acid activates AMPK in endothelial cells.

  4. Findings suggest that ischemic factor stimulation of the blood brain barrier Na-K-Cl cotransporter (显示 SLC12A1 抗体) involves activation of AMPK.

  5. Results suggest that mitochondria-derived superoxide anions and peroxynitrite are required for Berberine-induced AMPK activation in endothelial cells.

  6. the expression, but not the kinase activity, of AMPK and CaMKKbeta is necessary for ADP signaling to eNOS (显示 NOS3 抗体)

Human Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. The metformin-rescued P23H rhodopsin (显示 RHO 抗体) was still intrinsically unstable and led to increased structural instability of the rod outer segments. These data suggest that improving the traffic of misfolding rhodopsin (显示 RHO 抗体) mutants is unlikely to be a practical therapy, but also highlights the potential of altering translation through AMPK to improve protein function in other protein misfolding diseases

  2. These results suggest that the LKB1 (显示 STK11 抗体)-AMPK-FoxO1 (显示 FOXO1 抗体) signaling pathway is a critical mediator of the antioxidant properties of H2, further supporting the idea that H2 acts as a signaling molecule to serve various physiological functions.

  3. this study shows taht AMPK reduces abnormal inflammatory responses and cellular senescence, which implicates as a potential therapeutic target for chronic obstructive pulmonary disease/emphysema

  4. Salusin-beta mediates high glucose-induced endothelial injury via disruption of AMPK signaling pathway.

  5. These findings identify a key mechanism of tolerance to Ras-Raf (显示 RAF1 抗体) pathway inhibitors and suggest that blocking either AMPK or autophagy in combination with these targeted inhibitors could increase tumor regression and decrease the likelihood of eventual recurrence.

  6. the Runx2 (显示 RUNX2 抗体) knockdown cells displayed activation of AMP-activated protein kinase (AMPKalpha (显示 GRK4 抗体)), the sensor of cellular metabolism. Importantly, the Runx2 (显示 RUNX2 抗体) knockdown in bone-derived cells resulted in increased sensitivity to both Erk1/2 (显示 MAPK1/3 抗体) inhibition and AMPKalpha (显示 GRK4 抗体) activation by PD184161 and metformin, respectively, despite increased IGF-1Rbeta and AMPKalpha (显示 GRK4 抗体) levels.

  7. Data indicate that siRNA-mediated knockdown of AMP-activated protein kinase (显示 PRKAA2 抗体) alpha (显示 PAK1 抗体) subunit (显示 POLG 抗体) AMPKalpha1 inhibited icaritin-induced autophagy activation, but exacerbated colorectal cancer (CRC (显示 CALR 抗体)) cell death.

  8. Retinoid-related orphan receptor alpha (RORalpha) reduction occurs in gastric cancer leading to the survival of tumor cells, which is attenuated by AMP-activated protein kinase (AMPK (显示 PRKAA2 抗体)), therefore, both RORalpha and AMPK are potential targets for the intervention and therapy in gastric carcinoma.

  9. BCLB (显示 BCL2L10 抗体) expression was a starvation stress sensor inducing apoptosis and autophagy simultaneously in HCC (显示 FAM126A 抗体) cells through the adenosine monophosphate-activated protein kinase AMPK (显示 GRK4 抗体)-mTOR (显示 FRAP1 抗体) signaling cascade.

  10. findings show that dengue virus ( DENV) infection activates and requires the central metabolic regulator AMPK for its replication and the induction of lipophagy. This is required for the induction of lipophagy, but not basal autophagy, in DENV-infected cells

Zebrafish Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. AMPK-related pathways may be compromised during fluoxetine exposure as a result of increased miRNA abundance.

Xenopus laevis Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. Constitutively active AMPKgammaR70Q significantly decreases Napi-IIa (显示 SLC34A1 抗体) oocyte cell membrane abundance, an effect not mimicked by catalytically-inactive AMPKalphaK45R.

  2. NDPK-A (显示 NME1 抗体) exists in a functional cellular complex with AMPK (显示 PRKAA2 抗体) and CFTR (显示 CFTR 抗体) in airway epithelia, and NDPK-A (显示 NME1 抗体) catalytic function is required for the AMPK (显示 PRKAA2 抗体)-dependent regulation of CFTR (显示 CFTR 抗体)

Pig (Porcine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. Klotho (显示 KL 抗体) gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (显示 GRK4 抗体)-RUNX2 (显示 RUNX2 抗体) pathway.

  2. AMPK-mTOR (显示 FRAP1 抗体)-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.

  3. Data indicate that 17beta-estradiol reduced Sertoli Cell proliferation by inhibiting microRNA miR (显示 MYLIP 抗体)-1285 and thus activating AMP-activated protein kinase (AMPK (显示 PRKAA2 抗体)).

  4. L-Glutamine (显示 GFPT2 抗体) enhances enterocyte growth but did not affect abundances of total or phosphorylated AMPK protein.

  5. AMPK activity plays an important role in the maintenance of the spermatozoa quality during long-term storage of boar semen.

  6. AMPK, lying downstream of PKA, regulates at different levels mammalian spermatozoa membrane function.

  7. Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK/ERK (显示 MAPK1 抗体)/TSC2 (显示 TSC2 抗体)/mTOR (显示 FRAP1 抗体) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis

  8. AMPK deficiency or inhibition attenuated or mitigated ethanol exposure-triggered glucose intolerance and compromised cardiac contraction by increased phosphorylation of AMPK and acetyl-CoA carboxylase as well as autophagosome accumulation.

  9. AMPK functions to inhibit IGF-I (显示 IGF1 抗体)-stimulated PI3K pathway activation through stimulation of IRS-1 (显示 IRS1 抗体) serine 794 phosphorylation.

  10. acute activation of AMPK increases intestinal glucose absorption after administration of long-chain n-3 polyunsaturated fatty acids during gestation

PRKAA1 抗原简介

Antigen Summary

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Alternative names and synonyms associated with PRKAA1

  • protein kinase, AMP-activated, alpha 3 catalytic subunit (Prkaa3) 抗体
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (PRKAA1) 抗体
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (prkaa1) 抗体
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (Prkaa1) 抗体
  • AI194361 抗体
  • AI450832 抗体
  • AL024255 抗体
  • AMPK 抗体
  • AMPK1 抗体
  • AMPKa1 抗体
  • AMPKalpha1 抗体
  • C130083N04Rik 抗体
  • cb116 抗体
  • im:7154392 抗体
  • PRKAA1 抗体
  • sb:cb130 抗体
  • wu:fa94c10 抗体

Protein level used designations for PRKAA1

protein kinase, AMP-activated, alpha 3 catalytic subunit , protein kinase, AMP-activated, alpha 1 catalytic subunit , 5'-AMP-activated protein kinase catalyti subunit alpha-1-like protein , 5'-AMP-activated protein kinase catalytic subunit alpha-1 , AMPK-activated protein kinase alpha-1 subunit , 5'-AMP-activated protein kinase alpha 1 catalytic subunit , 5'-AMP-activated protein kinase, catalytic alpha-1 chain , ACACA kinase , AMP -activate kinase alpha 1 subunit , AMP-activated protein kinase, catalytic, alpha-1 , AMPK alpha 1 , AMPK subunit alpha-1 , HMGCR kinase , acetyl-CoA carboxylase kinase , hydroxymethylglutaryl-CoA reductase kinase , tau-protein kinase PRKAA1 , AMPK alpha-1 chain , AMP-activated protein kinase, alpha 1 catalytic subunit , ampka1 , 5'-AMP-activated protein kinase alpha-1 catalytic subunit , AMPKalpha1 , 63 kDa subunit , AMPK 63 kDa subunit

GENE ID SPECIES
108080 Mus musculus
100009710 Equus caballus
100034740 Meleagris gallopavo
100145520 Xenopus (Silurana) tropicalis
100294665 Ovis aries
540404 Bos taurus
5562 Homo sapiens
65248 Rattus norvegicus
105787 Mus musculus
100001198 Danio rerio
495290 Xenopus laevis
427185 Gallus gallus
479351 Canis lupus familiaris
100145903 Sus scrofa
100174304 Pongo abelii
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