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MyoD (显示 MYOD1 ELISA试剂盒) regulates the oxidative metabolic capacity of adult skeletal muscle;ChIP-seq analysis identified MyoD (显示 MYOD1 ELISA试剂盒) binding on the PGC (显示 PGC ELISA试剂盒)-1b, but not PGC (显示 PGC ELISA试剂盒)-1a, gene locus;MyoD (显示 MYOD1 ELISA试剂盒) cooperates with alternative NF-kappaB (显示 NFKB1 ELISA试剂盒) to regulate PGC (显示 PGC ELISA试剂盒)-1b transcription; MyoD (显示 MYOD1 ELISA试剂盒) and RelB (显示 RELB ELISA试剂盒) co-occupy many other genes involved in aerobic respiration
We conclude that while activation of muscle PGC-1beta is sufficient to drive the complete endurance phenotype in sedentary mice, it only partially prevents the detraining response following exercise training, suggesting that the process of endurance detraining involves mechanisms beyond the reversal of muscle autonomous mechanisms involved in endurance fitness.
Data suggest that PGC-1alpha (显示 PPARGC1A ELISA试剂盒) and -1beta expression are not required for training-induced exercise performance, highlighting the contribution of PGC-1 (显示 PPARGC1A ELISA试剂盒)-independent mechanisms.
We confirmed that PGC (显示 PGC ELISA试剂盒)-1b inhibited downstream inflammatory signals via binding with TAB1 (显示 TAB1 ELISA试剂盒) and thus preventing TAB1 (显示 TAB1 ELISA试剂盒)/TAK1 (显示 NR2C2 ELISA试剂盒) binding and TAK1 (显示 NR2C2 ELISA试剂盒) activation.
the anti-inflammatory environment in muscle promoted by the PGC (显示 PGC ELISA试剂盒)-1s might contribute to the beneficial effects of these coactivators on muscle function and provides a molecular link underlying the tight mutual regulation of metabolism and inflammation
PGC1beta represses proangiogenic genes and stimulates antiangiogenic genes in muscle ischemia. PGC1beta inhibits neoangiogenesis and blocks ischemic revascularization.
The data indicate a novel detrimental age-dependent role of PPAR beta (显示 PPARD ELISA试剂盒)/delta in Alzheimer disease by increasing pro-BDNF (显示 BDNF ELISA试剂盒) and decreasing BDNF (显示 BDNF ELISA试剂盒)/TrkB (显示 NTRK2 ELISA试剂盒) survival pathways.
The results highlight a novel function for SYVN1 (显示 SYVN1 ELISA试剂盒) in the control of body weight and mitochondrial biogenesis through negative regulation of PGC (显示 PGC ELISA试剂盒)-1b.
PGC-1beta in the gut (显示 GUSB ELISA试剂盒) acts as an adaptive self-point regulator, capable of providing a balance between enhanced mitochondrial activity and protection from increased ROS (显示 ROS1 ELISA试剂盒) production
Fisetin regulates the expression of hepatic lipid metabolism genes by downregulating miR (显示 MLXIP ELISA试剂盒)-378 and the host gene PGC-1beta.
The presence of the PPARGC1B (Ala203Pro) SNP did not modify the association between inorganic arsenic methylation capacity and breast cancer.
Genetic variants of PPARGC1B are significantly associated with gout, and a missense single nucleotide polymorphism, rs45520937, augments NLRP3 (显示 NLRP3 ELISA试剂盒) and IL-1beta (显示 IL1B ELISA试剂盒) expression
the forkhead box O3 (FOXO3 (显示 FOXO3 ELISA试剂盒))/liver kinase B1 (LKB1 (显示 STK11 ELISA试剂盒))/AMP-activated protein kinase (显示 PRKAA2 ELISA试剂盒)/peroxisome proliferator-activated receptor-gamma (显示 PPARG ELISA试剂盒) co-activator-1beta (PGC-1beta)/pyruvate dehydrogenase (显示 PDP ELISA试剂盒)-A1 pathway is essential for CD44 (显示 CD44 ELISA试剂盒) expression and cancer stem cells properties.
We also suggest a novel hepatic protective role of PGC1B as a modulator of E2 effects on mitochondrial biogenesis
we show an association of HER2 (显示 ERBB2 ELISA试剂盒)-overexpression and PGC-1beta. PGC-1beta knockdown impairs HER2 (显示 ERBB2 ELISA试剂盒)-overexpressing cells proliferation acting on ERRalpha (显示 ESRRA ELISA试剂盒) signaling, metabolism, and redox balance.
Further replication study confirmed the association signals of rs4705372 (P = 0.0026) and rs11743128 (P = 0.0387) in the independent validation sample. Our study results suggest that PPARGC1B is a novel susceptibility gene of Kashin-Beck disease .
Human influenza hemagglutinin (显示 HA ELISA试剂盒)-tagged PPARGC1B coprecipitated more intensely with ERalpha (显示 ESR1 ELISA试剂盒) in the +102525A than the +102525G construct after 17beta estradiol treatment
Data suggest that PGC-1alpha (显示 PPARGC1A ELISA试剂盒) and PGC-1beta could play a role in regulating retina cell survival, and may be therapeutic targets to prevent retinal degeneration.
PGC-1(beta) and estrogen-related receptor alpha (显示 ESRRA ELISA试剂盒) are aberrantly expressed in human colon cell lines and tumors.
RUNX3 (显示 RUNX3 ELISA试剂盒) is related to both the severity of AS and the function of daily life. PPARGC1B is related to the function of daily life.
The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene.
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
, peroxisome proliferator-activated receptor gamma coactivator 1-beta-like
, ERR ligand 1
, PPAR gamma coactivator-1beta protein
, PPAR-gamma coactivator 1-beta
, peroxisome proliferator-activated receptor gamma coactivator 1 beta
, peroxisome proliferator-activated receptor gamma coactivator 1-beta
, peroxisome proliferative activated receptor, gamma, coactivator 1 beta
, peroxisome proliferator-activated receptor gamma coactivator 1beta-2a
, PGC-1-related estrogen receptor alpha coactivator