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Atg38 and its human ortholog NRBF2 (显示 NRBF2 ELISA试剂盒), accessory components of complex I consisting of Vps15-Vps34-Vps30/Atg6 (显示 BECN1 ELISA试剂盒)-Atg14 (yeast) and PIK3R4/VPS15-PIK3C3/VPS34-BECN1/Beclin 1 (显示 BECN1 ELISA试剂盒)-ATG14 (human), were characterized.
p300 (显示 EP300 ELISA试剂盒)-dependent VPS34 acetylation/deacetylation is the physiological key to VPS34 activation, which controls the initiation of canonical autophagy and of non-canonical autophagy in which the upstream kinases of VPS34 can be bypassed.
Low VPS34 expression is associated with cancer.
Arf tumor suppressor as a new transcriptional target of nuclear EGFR and highlight Vps34 as an important regulator of the nuclear EGFR/Arf survival pathway.
Vps34 has a previously unknown role in regulating Rab7 (显示 RAB7B ELISA试剂盒) activity and late endosomal trafficking.
High expression of VPS34 promoted GRP78 (显示 HSPA5 ELISA试剂盒) transcription by modulating ATF6 (显示 ATF6 ELISA试剂盒). VPS34 could enhance GRP78 (显示 HSPA5 ELISA试剂盒) protein stability.
These results establish Vps34 as an essential determinant of both short-term and long-term canonical GPCR signaling.
Study identifies a key role of Cul3 (显示 CUL3 ELISA试剂盒)-KLHL20 (显示 KLHL20 ELISA试剂盒) in autophagy termination by controlling autophagy-dependent turnover of ULK1 (显示 ULK1 ELISA试剂盒) and VPS34 complex subunits and reveals the pathophysiological functions of this autophagy termination mechanism.
cis (显示 CISH ELISA试剂盒)-unsaturated fatty acids require neither BECN1 (显示 BECN1 ELISA试剂盒) nor PIK3C3 to stimulate the autophagic flux
tubulation requires mTOR (显示 FRAP1 ELISA试剂盒) activity, and we identified two direct mTOR (显示 FRAP1 ELISA试剂盒) phosphorylation sites on UVRAG (S550 and S571) that activate VPS34.
These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
confirmed that the polymorphism in PIK3C3 (C2604T) has the potential to be a genetic marker for production traits in Duroc pigs
This study uncovers a dual role for Vps34 as a regulator of platelet production by megakaryocytes and as an unexpected regulator of platelet activation and arterial thrombus formation dynamics.
E. chaffeensis secretes Etf-1 (显示 ETF1 ELISA试剂盒) to induce autophagy to repurpose the host cytoplasm and capture nutrients for its growth through RAB5 (显示 RAB5A ELISA试剂盒) and class III PtdIns3K, while avoiding autolysosomal killing.
p300 (显示 NOTCH1 ELISA试剂盒)-dependent VPS34 acetylation/deacetylation is the physiological key to VPS34 activation, which controls the initiation of canonical autophagy and of non-canonical autophagy in which the upstream kinases of VPS34 can be bypassed.
Vps34 has a previously unknown role in regulating Rab7 (显示 RAB7A ELISA试剂盒) activity and late endosomal trafficking.
PIK3C3 was strongly expressed in the axon of cortical neurons during brain development.
provide the novel evidence that GADD45A (显示 GADD45A ELISA试剂盒) inhibits autophagy via impairing the BECN1 (显示 BECN1 ELISA试剂盒)-PIK3C3 complex formation
PAQR3 controls autophagy by integrating AMPK (显示 PRKAA1 ELISA试剂盒) signaling to enhance ATG14L-associated PI3K activity
Depletion of hepatic Vps15, the regulatory subunit of class III PI3K, increases insulin (显示 INS ELISA试剂盒) sensitivity and Akt (显示 AKT1 ELISA试剂盒) signaling.
Beclin 1 (显示 BECN1 ELISA试剂盒) regulates endosome pathways via the UVRAG-VPS34 complex.
Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis (By similarity).
phosphoinositide-3-kinase, class 3
, phosphatidylinositol 3-kinase catalytic subunit type 3
, PI3K type 3
, PI3-kinase type 3
, ptdIns-3-kinase type 3
, phosphoinositide-3-kinase class 3
, catalytic phosphatidylinositol 3-kinase 3
, PtdIns-3-kinase type 3
, phosphatidylinositol 3-kinase p100 subunit
, class 3 phosphoinositide-3-kinase
, PI-3K Vps34p