anti-HMGCR (HMGCR) 抗体产品概述

Full name:
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase 抗体 (HMGCR)
在www.antibodies-online.cn可供86 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) 抗体的16不同的供货商。 再加上,我们可以发HMGCR 试剂盒 (29)HMGCR 蛋白 (4)和数多这个蛋白质的别的产品。 总共125 HMGCR产品已列进来了。
别名:
3H3M, BcDNA:LD15354, bro1, bs32f05.y1, CG10367, clb, Dmel\\CG10367, DmHMG-CoAr, Hmg, hmg-coa-r, HMG-CoAR, hmgc, HMGCoAr, HMGCoARr, hmgcr, HMGCR_Dm, HMGR, hmgrc, l(3)01152, l(3)04684, LDLCQ3, Red

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引用最多的anti-HMGCR 抗体

  1. Human Polyclonal HMGCR Primary Antibody for IF (p), IHC (p) - ABIN709196 : Wu, He, Wang, Xue, Ning, Zou, Ye, Li, Wang, Pang: The antihypercholesterolemic effect of jatrorrhizine isolated from Rhizoma Coptidis. in Phytomedicine : international journal of phytotherapy and phytopharmacology 2014 (PubMed)
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  2. Human Polyclonal HMGCR Primary Antibody for ICC, IF - ABIN4319308 : Bjarnadottir, Romero, Bendahl, Jirström, Rydén, Loman, Uhlén, Johannesson, Rose, Grabau, Borgquist: Targeting HMG-CoA reductase with statins in a window-of-opportunity breast cancer trial. in Breast cancer research and treatment 2013 (PubMed)
    Show all 4 references for 4319308

更多抗HMGCR的相互作用对抗体

Fruit Fly (Drosophila melanogaster) 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) interaction partners

  1. The specificity and evolutionary conservation of the HMGCoAr pathway for germ cells suggest that an attractant common to invertebrates and vertebrates guides germ cells in early embryos.

Human 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) interaction partners

  1. To estimate the association between changes in levels of LDL-C (and other lipoproteins) and the risk of cardiovascular events related to variants in the CETP (显示 CETP 抗体) gene, both alone and in combination with variants in the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) gene.

  2. Low LDL cholesterol levels due to PCSK9 (显示 PCSK9 抗体) and HMGCR variants had no causal effect on high risk of Alzheimer's disease, vascular dementia, any dementia, or Parkinson's disease; however, low LDL cholesterol levels may have a causal effect in reducing the risk of Alzheimer's disease.

  3. These results indicate that HIF-mediated induction of Insig-2 (显示 INSIG2 抗体) and degradation of HMGCR are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia.

  4. TGF-beta1 (显示 TGFB1 抗体) induces cholesterol synthesis by increasing HMG-CoA reductase mRNA expression in keratinocytes.

  5. Gene expression profile and the biological functions of HMGCR in gastric cancer were studied. It was found that the expression of HMGCR was increased in gastric cancer tissues. Over-expression of HMGCR promoted the growth and migration of gastric cancer cells, while knocking down the expression of HMGCR inhibited the growth, migration and tumorigenesis of gastric cancer cells.

  6. In this study, variants in PCSK9 (显示 PCSK9 抗体) had approximately the same effect as variants in HMGCR on the risk of cardiovascular events and diabetes per unit decrease in the LDL cholesterol level. The effects of these variants were independent and additive.

  7. Data show that simvastatin significantly inhibited cellular proliferation, induced cell cycle G1 arrest and apoptosis, and caused cellular stress via reduction in the enzymatic activity of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR).

  8. no associations found between HMGCR rs3846662, HMRCR alternative splicing and Alzheimer's disease pathology pathology.

  9. results indicate that abnormal lipid metabolism may exist in spontaneous preterm delivery (SPTD) women and the premature fetus and the HMGCR gene may be a susceptible gene for SPTD

  10. Report the mechanism of polyphenol binding to and activity regulation of HMGR (显示 HMGA1 抗体) using molecular docking.

Pig (Porcine) 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) interaction partners

  1. The relative expression level of HMGR was high in liver, heart, kidney, bladder and subcutaneous fat, medium in lung, uterus and large intestine, and low in cerebrum, spleen, spinal cord, stomach, ovary, longissimus muscle, and small intestine.

Mouse (Murine) 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) interaction partners

  1. These results indicate that HIF-mediated induction of Insig-2 (显示 INSIG2 抗体) and degradation of HMGCR are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia.

  2. these studies designate sterol-accelerated degradation of HMGCR as a potential therapeutic target for prevention of atherosclerosis and associated cardiovascular disease.

  3. To eludicate the mechanisms underlying statin myotoxicity and HMGCR function in skeletal muscle, we developed the skeletal muscle-specific (显示 EIF3K 抗体) HMGCR knockout mice.

  4. High-dose simvastatin inhibits HMGCoA reductase and prevents experimental hyperinflation lung injury by angioprotective and anti-inflammatory effects.

  5. TSH can regulate the phosphorylation of HMGCR via AMPK (显示 PRKAA1 抗体).

  6. HMGCR proteasomal-degradation by IFN strictly requires the synthesis of endogenous 25-Hydroxycholesterol.

  7. Increased cholesterol synthesis mediated by HMGCoA (显示 HMGCS2 抗体)-R under inflammatory stress may be one of the mechanisms for intracellular lipid accumulation and statin resistance.

  8. we consistently observe involvement of gp78 (显示 AMFR 抗体) in Insig-1 (显示 INSIG1 抗体) degradation, we find no substantive evidence to support roles for either gp78 (显示 AMFR 抗体) or TRC8 (显示 RNF139 抗体) in the robust sterol-accelerated degradation of HMG-CoA reductase.

  9. Hepatocyte HMGCR is essential for the survival of mice, and its abrogation elicits hepatic steatosis with jaundice and hypoglycemia.

  10. Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms.

HMGCR 抗原简介

Antigen Summary

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with HMGCR

  • HMG Coenzyme A reductase (Hmgcr) 抗体
  • 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) 抗体
  • 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr) 抗体
  • 3-hydroxy-3-methylglutaryl-CoA reductase (hmgcr) 抗体
  • 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr) 抗体
  • 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (LOC100357791) 抗体
  • 3H3M 抗体
  • BcDNA:LD15354 抗体
  • bro1 抗体
  • bs32f05.y1 抗体
  • CG10367 抗体
  • clb 抗体
  • Dmel\\CG10367 抗体
  • DmHMG-CoAr 抗体
  • Hmg 抗体
  • hmg-coa-r 抗体
  • HMG-CoAR 抗体
  • hmgc 抗体
  • HMGCoAr 抗体
  • HMGCoARr 抗体
  • hmgcr 抗体
  • HMGCR_Dm 抗体
  • HMGR 抗体
  • hmgrc 抗体
  • l(3)01152 抗体
  • l(3)04684 抗体
  • LDLCQ3 抗体
  • Red 抗体

Protein level used designations for HMGCR

3-Hydroxy-3-Methylglutaryl CoA reductase , 3-hydroxy-3-methylglutaryl coenzyme A reductase , CG10367-PA , HMG coenzyme A reductase , HMG-CoA reductase , HMGCo-A reductase , HMGCoA reductase , Hmg-CoA-reductase , Hmgcr-PA , columbus , lethal (3) 04684 , 3-hydroxy-3-methylglutaryl CoA reductase (NADPH) , 3-hydroxy-3-methylglutaryl-Coenzyme A reductase , hydroxymethylglutaryl-CoA reductase , 3-hydroxy-3-methylglutaryl coenzyme A reductase/HMG-CoA reductase , 3-hydroxy-3-methylglutaryl-coenzyme A reductase , 3-hydroxy-3-methylglutaryl CoA reductase , 3-hydroxy-3-methylglutaryl-CoA reductase

GENE ID SPECIES
42803 Drosophila melanogaster
3156 Homo sapiens
479182 Canis lupus familiaris
100144446 Sus scrofa
407159 Bos taurus
25675 Rattus norvegicus
395145 Gallus gallus
397750 Xenopus laevis
100173499 Pongo abelii
15357 Mus musculus
100357791 Oryctolagus cuniculus
100756363 Cricetulus griseus
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