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the direct interaction of AKT2 (显示 AKT2 ELISA试剂盒) and EF2 was found to be dynamically regulated in embryonic rat cardiomyocytes
These results suggest that binding of eEF2 to the ribosome alters its conformation, resulting in a weakened affinity of eIF5A (显示 EIF5 ELISA试剂盒) and impairment of this interplay compromises cell growth due to translation elongation defects.
nuclear localization of active eEF-2 depends upon its interaction with p53 (显示 TP53 ELISA试剂盒), as cells lacking p53 (显示 TP53 ELISA试剂盒) contain less active eEF-2 in the nuclear compartment
High serum eukaryotic elongation factor 2 level is associated with non-small cell lung cancer.
Results indicated that the eEF2 gene is overexpressed in the majority of several types of cancers and plays an oncogenic role in cancer cell growth.
The expression levels of three putative HA-regulated proteins (TALDO, ANXA1 (显示 ANXA1 ELISA试剂盒) and EF2) in control, H2O2-, HA- and HA/H2O2-treated OA chondrocytes were verified by Western blotting and the results indeed support the notion that HA acts in anti-oxidation
Data indicate that the accumulation of the cleaved C-terminal small fragment of eukaryotic elongation factor 2 (eEF2) in the nucleus, and C-terminal Src kinase (Csk (显示 CSK ELISA试剂盒)) could enhance the proteolytic cleavage of eEF2.
Thiopental inhibits global protein synthesis by repression of eukaryotic elongation factor 2 and protects from hypoxic neuronal cell death.
A single amino acid substitution in eukaryotic elongation factor 2 co-segregates with the disease phenotype of spinocerebellar ataxia 26.
EEF2 phosphorylation by cyclin A (显示 CCNA2 ELISA试剂盒)-cyclin-dependent kinase 2 (CDK2 (显示 CDK2 ELISA试剂盒)) on a novel site, serine 595 (S595), directly regulates T56 phosphorylation by eEF2K (显示 EEF2K ELISA试剂盒).
IL-6 (显示 IL6 ELISA试剂盒) induces the activation of the Stat3 (显示 STAT3 ELISA试剂盒) signaling and promotes the downmodulation of the p90RSK (显示 RPS6KA1 ELISA试剂盒)/eEF2 and mTOR (显示 FRAP1 ELISA试剂盒)/p70S6K (显示 RPS6KB1 ELISA试剂盒) axes, while it does not affect the activation of AKT (显示 AKT1 ELISA试剂盒).
AMPKalpha2 (显示 PRKAA2 ELISA试剂盒) controls cardiac p70S6K (显示 RPS6KB1 ELISA试剂盒) under normoxia and regulates eEF-2 but not the mTOR (显示 FRAP1 ELISA试剂盒)-p70S6K (显示 RPS6KB1 ELISA试剂盒) pathway during ischemia.
The MKK3 (显示 MAP2K3 ELISA试剂盒)/6-p38gamma (显示 MAPK12 ELISA试剂盒)/delta pathway mediated an inhibitory phosphorylation of eukaryotic elongation factor 2 (eEF2) kinase, which in turn promoted eEF2 activation (dephosphorylation) and subsequent TNF-alpha (显示 TNF ELISA试剂盒) elongation.
Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development
induced by basic fibroblast growth factor (显示 FGF2 ELISA试剂盒) via mitogen-activated protein kinase (显示 MAPK1 ELISA试剂盒)
eEF-2 is activated by both lithium and GSK-3 (显示 GSK3b ELISA试剂盒), whereas, lithium treatment and inhibition of GSK-3 (显示 GSK3b ELISA试剂盒) have opposing effects on eEF-2.
eEF-2 phosphorylation has a role in protein synthesis for memory consolidation
A mouse that was mutant for the gene, Dph4 (显示 DNAJC24 ELISA试剂盒), was identified.
exogenous ROS (显示 ROS1 ELISA试剂盒) inhibit mTOR (显示 FRAP1 ELISA试剂盒), eIF2alpha (显示 EIF2A ELISA试剂盒), and eEF2, mTOR (显示 FRAP1 ELISA试剂盒) and eEF2 were largely refractory to ROS (显示 ROS1 ELISA试剂盒) generated under moderate hypoxia (0.5% O(2)).
Eukaryotic elongation factor-2 (eEF2) may be a limiting factor in milk protein (显示 CSN2 ELISA试剂盒) synthesis (Review)
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation.
eukaryotic translation elongation factor 2
, elongation factor 2-like
, elongation factor 2
, polypeptidyl-tRNA translocase
, elongation factor-2