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CRTC2 polymorphism as a risk factor for the incidence of metabolic syndrome in transplant recipients after solid organ transplantation.
CRTC2 strongly enhances GR-induced transcriptional activity of glucocorticoid-responsive genes.
Our results establish a role for CRTC2 as a lymphoma tumor suppressor gene
the high expression of CRTC2 and PROM1 may play an important role in the occurrence and hereditary, and also advance the potential pathways that integrate genetic variants in the development of NSCLC.
The data from the current study demonstrated novel PROM1 and CRTC2 mutations, which could promote lung cancer development.
These results clearly indicate that non-phosphorylated CRTC2 strongly enhances hepatitis b virus biosynthesis through inducing PGC1alpha expression.
Phosphorylation of CRTC2 at its AMPK (显示 PRKAA1 蛋白) target site, Ser (显示 SIGLEC1 蛋白) 171, dictated its subcellular localization, and the activation of aromatase (显示 CYP19A1 蛋白) PII in preadipocytes.
CRTC2 enhances CREB (显示 CREB1 蛋白) phosphorylation through an association with the protein arginine methyltransferase 5 (PRMT5 (显示 PRMT5 蛋白)).
Mechanism of CREB (显示 CREB1 蛋白) recognition and coactivation by the CREB (显示 CREB1 蛋白)-regulated transcriptional coactivator CRTC2
The lipogenic effects of GIP (显示 GIP 蛋白) in the presence of insulin (显示 INS 蛋白) are therefore at least partially mediated by upregulation of adipocyte LPL (显示 LCP1 蛋白) gene transcription through a pathway involving PI3-K (显示 PIK3CA 蛋白)/PKB (显示 AKT1 蛋白)/AMPK (显示 PRKAA1 蛋白)-dependent CREB (显示 CREB1 蛋白)/TORC2 activation.
the existence of an unusual functional interplay between STATs and CREB (显示 CREB1 蛋白) at the onset of adipogenesis through shared CRTC cofactors, is reported.
CRTC2 play a role in hepatic cholesterol synthesis through SREBP-2 (显示 SREBF2 蛋白).
Catecholaminergic deletion of Rictor increases water, sucrose, and morphine intake but not preference in a two-bottle choice assay in stress-naive mice, and these effects are maintained after stress. Ventral Tegmental Area-specific knockout of Rictor increases water and sucrose intake after physical CSDS, but does not alter consummatory behavior in the absence of stress.
Three mouse CRTCs (Crtc1 (显示 CRTC1 蛋白), Crtc2 and Crtc3 (显示 CRTC3 蛋白)) exhibit distinct patterns of 14-3-3 (显示 YWHAQ 蛋白) binding at three conserved sites corresponding to S70, S171 (显示 NUMB 蛋白), and S275 (in CRTC2).
the protein expression of adipose tissue CRTC 2 was reduced in mice with a combined application of change to general diet and exercise. In addition, while the protein expressions of lipase (显示 LIPG 蛋白) ATGL (显示 PNPLA2 蛋白) and HSL (显示 LIPE 蛋白) were reduced in the mice fed with the high fat diet continually after obesity was induced
CRTC2 promotes Th17 cell differentiation via stimulation of IL-17A (显示 IL17A 蛋白) and IL-17F (显示 IL17F 蛋白) expression by binding to CREB (显示 CREB1 蛋白) over both promoters. CRTC2-mutant mice have decreased Th17 cells, and they are protected from experimental autoimmune encephalitis.
chronic increases in CRTC2 activity in the liver are indeed sufficient to promote hepatic insulin (显示 INS 蛋白) resistance and to disrupt glucose homeostasis
cAMP, SIK and CRTC mediate StAR expression through activation of individual StAR gene loci.
RICTOR/mTORC2 is important for interactions between vasculature, adipocytes, and brain to tune physiological outcomes, such as blood pressure and locomotor activity.
CREB regulated transcription coactivator 2 (CRTC2) functions as a mediator of mTOR (显示 FRAP1 蛋白) signalling to modulate COPII-dependent SREBP1 (显示 SREBF1 蛋白) processing
This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5.
CREB regulated transcription coactivator 2
, CREB-regulated transcription coactivator 2
, CREB-regulated transcription coactivator 2-like
, transducer of regulated cAMP response element-binding protein (CREB) 2
, transducer of CREB protein 2
, transducer of regulated cAMP response element-binding protein 2