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Apoptosis activator 2

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原理 An apoptosis activator
产品特性 Apoptosis activator 2 is a cell-permeable apoptosis activator that promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC₅₀ > 40 μM).
纯度 ≥ 98 % by HPLC
Chemical Name 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione
Formula C₁₅H₉Cl₂NO₂
Permeability Cell-permeable
Solubility DMSO (~ 30 mg/ml)
分子量 306.14 g/mol
CAS-编号 79183-19-0
限制 仅限研究用
状态 Solid
注意事项 Protect from air and light
储存条件 -20 °C
有效期 36 months