StemRegenin 1, Free base

ABIN1995247 产品详细信息, 供应商: Log in to see
应用范围
Functional Studies (Func), Activation (Act), Blocking Reagent (BR), Inhibition Assay (InhA)
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原理 A promoter of self-renewal of hematopoietic stem cells (HSCs)
产品特性 PubChem CID: 46199207
A cell-permeable purine derivative that acts as an antagonist of aryl hydrocarbon receptor and promotes the self-renewal of hematopoietic stem cells (HSCs). Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. In the absence of cytokines, StemRegenin 1 did not induce proliferation, and at concentrations above 1 µM, it inhibits proliferation.
纯度 ≥ 98 % by HPLC
Chemical Name 4-(2-((2-Benzo[b]thiphen-3-yl)-9-isopropyl-9H-purin-6-yl)amino)ethyl)phenol; SR1
Formula C₂₄H₂₃N₅OS
Permeability Cell-permeable
Solubility DMSO (~ 10 mg/ml)
分子量 429.54 g/mol
CAS-编号 1227633-49-9
限制 仅限研究用
状态 Solid
注意事项 Protect from air and light
储存条件 -20 °C
有效期 48 months
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