BAX Activator, BAM7

ABIN1888932 产品详细信息, 供应商: Log in to see
应用范围
Activation (Act)
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原理 A potent and selective BAX activator
产品特性 A potent and selective BAX activator (EC₅₀ = 3.3 μM). BAM7 directly binds at the BH3-binding site, selective for BAX over other antiapoptotic and proapoptotic proteins. BAM7 triggers in vitro BAX oligomerization, BAX-mediated pore formation and BAX-dependent cell death. BAM7 selectively induces BAX-mediated apoptosis by triggering the hallmark features of intracellular BAX activation. BAM7 only kills the cell line that contains BAX, eliciting the biochemical and morphologic features of BAX-mediated apoptosis.
纯度 ≥ 98 % by HPLC
Chemical Name 3-Methyl-1-(4-phenyl-2-thiazolyl)-1​H-pyrazole-4,5-dione 4-[2-(2-Ethoxyphenyl)hydrazone]; BAM7
Formula C₂₁H₁₉N₅O₂S
Permeability Cell-permeable
分子量 405.47 g/mol
CAS-编号 331244-89-4
限制 仅限研究用
状态 Solid
注意事项 Protect from air and light
储存条件 -20 °C
有效期 24 months
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