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PYD and CARD Domain Containing ELISA试剂盒 (PYCARD)
在www.antibodies-online.cn可供8 PYD and CARD Domain Containing (PYCARD) ELISA试剂盒的4不同的供货商。 再加上,我们可以发PYCARD 抗体 (154)PYCARD 蛋白 (8)和数多这个蛋白质的别的产品。 总共182 PYCARD产品已列进来了。
9130417A21Rik, Asc, asc1, CARD5, masc, TMS, TMS-1, TMS1, TNS1, zAsc, zgc:109874
list all ELISA KIts 基因 基因ID UniProt
大鼠 PYCARD PYCARD 282817  



PYCARD (PYCARD) ELISA试剂盒 by Reactivity

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适于 PYCARD 相互作用对的更多 ELISA 试剂盒

Human PYD and CARD Domain Containing (PYCARD) interaction partners

  1. besides its role in the inhibition of the NF-kappaB (显示 NFKB1 ELISA试剂盒) pathway, NLRC3 (显示 NLRC3 ELISA试剂盒) interferes with the assembly and activity of the NALP3 (显示 NLRP3 ELISA试剂盒) inflammasome complex by competing with ASC for pro-caspase-1 (显示 CASP1 ELISA试剂盒) binding

  2. ASC Induces Apoptosis via Activation of Caspase-9 (显示 CASP9 ELISA试剂盒) by Enhancing Gap Junction-Mediated Intercellular Communication.(

  3. These data revealed that cross-linking of ASC(PYD) filaments via ASC(CARD) mediates the assembly of ASC foci.

  4. Down-regulation of mRNA expression was found in cases in which CASP8 (显示 CASP8 ELISA试剂盒), TMS1 (显示 SERINC3 ELISA试剂盒) and DAPK (显示 DAPK1 ELISA试剂盒) were hypermethylated.

  5. loss of ASC driven tumor development is counterbalanced in the identical cell by the inhibition of pro-tumorigenic inflammation in the tumor cell itself

  6. the deubiquitinating enzyme USP50 binds to the ASC protein and subsequently regulates the inflammasome signaling pathway.

  7. ASC self-associates and binds NLRP3 (显示 NLRP3 ELISA试剂盒) PYD through equivalent protein regions, with higher binding affinity for the latter. These regions are located at opposite sides of the protein allowing multimeric complex formation previously shown in ASC PYD fibril assemblies.

  8. Our data identify RIPK3 (显示 RIPK3 ELISA试剂盒) and the ASC inflammasome as key tumor suppressors in AML (显示 RUNX1 ELISA试剂盒).

  9. The role of the danger signals ASC and HMGB1 (显示 HMGB1 ELISA试剂盒) in the Fusobacterium nucleatum infection of gingival epithelial cells.

  10. Data show that NOD-like receptor signaling genes NOD2 (显示 NOD2 ELISA试剂盒), PYCARD, CARD6 (显示 CARD6 ELISA试剂盒), and IFI16 (显示 IFI16 ELISA试剂盒) are upregulated in psoriatic epidermis.

Mouse (Murine) PYD and CARD Domain Containing (PYCARD) interaction partners

  1. this study shows that ASC (显示 STS ELISA试剂盒)-dependent Inflammasomes do not shape the commensal gut (显示 GUSB ELISA试剂盒) microbiota composition

  2. Our data identify RIPK3 (显示 RIPK3 ELISA试剂盒) and the ASC (显示 STS ELISA试剂盒) inflammasome as key tumor suppressors in AML (显示 RUNX1 ELISA试剂盒).

  3. Data show that T cell-intrinsic PYD and CARD domain containing protein ASC is required for TH17-mediated experimental autoimmune encephalomyelitis (EAE).

  4. Data suggest that interleukin 22 (IL-22 (显示 IL22 ELISA试剂盒)) plays a pro-inflammatory/pathogenic role in the onset of antigen-induced arthritis (AIA) through apoptosis-associated speck-like Pycard protein (ASC (显示 STS ELISA试剂盒))-dependent stimulation of interleukin-1 beta (IL-1beta (显示 IL1B ELISA试剂盒)) production.

  5. report herein that lack of ASC (显示 STS ELISA试剂盒) does not confer preferential protection in response to P. aeruginosa acute infection and that ASC (显示 STS ELISA试剂盒)(-/-) mice are capable of producing robust amounts of IL-1beta (显示 IL1B ELISA试剂盒) comparable with C57BL/6 mice

  6. These data identify a novel non-canonical immunoregulatory function of NLRP3 (显示 NLRP3 ELISA试剂盒) and ASC (显示 STS ELISA试剂盒) in autoimmunity.

  7. a significant role for NLRP3 (显示 NLRP3 ELISA试剂盒) and ASC (显示 STS ELISA试剂盒) in prion (显示 PRNP ELISA试剂盒) pathogenesis

  8. ASC (显示 STS ELISA试剂盒)-driven caspase-1 (显示 CASP1 ELISA试剂盒) autoprocessing and speck formation are dispensable for the activation of caspase-1 (显示 CASP1 ELISA试剂盒) and the NLRP1b inflammasome.

  9. IKKalpha (显示 CHUK ELISA试剂盒) controls the inflammasome at the level of the adaptor molecule ASC (显示 STS ELISA试剂盒), which interacts with IKKalpha (显示 CHUK ELISA试剂盒) in the nucleus of resting macrophages in an IKKalpha (显示 CHUK ELISA试剂盒) kinase-dependent manner.

  10. Hypoxia-induced elevated right ventricular pressure and remodeling were attenuated in mice lacking the inflammasome adaptor protein ASC (显示 STS ELISA试剂盒), suggesting that inflammasomes play an important role in the pathogenesis of pulmonary hypertension.


Antigen Summary

This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm\; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PYCARD

  • PYD and CARD domain containing (PYCARD) Elisa Kit
  • PYD and CARD domain containing (Pycard) Elisa Kit
  • PYD and CARD domain containing (pycard) Elisa Kit
  • 9130417A21Rik Elisa Kit
  • Asc Elisa Kit
  • asc1 Elisa Kit
  • CARD5 Elisa Kit
  • masc Elisa Kit
  • TMS Elisa Kit
  • TMS-1 Elisa Kit
  • TMS1 Elisa Kit
  • TNS1 Elisa Kit
  • zAsc Elisa Kit
  • zgc:109874 Elisa Kit

Protein level used designations for PYCARD

apoptosis-associated speck-like protein containing a CARD , caspase recruitment domain-containing protein 5 , target of methylation-induced silencing 1 , PYD and CARD domain-containing protein

29108 Homo sapiens
66824 Mus musculus
282817 Rattus norvegicus
282846 Bos taurus
57923 Danio rerio