anti-ITCH (ITCH) 抗体产品概述

Full name:
anti-Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) 抗体 (ITCH)
在www.antibodies-online.cn可供78 Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) (ITCH) 抗体的21不同的供货商。 再加上,我们可以发ITCH 蛋白 (6)ITCH 试剂盒 (4)和数多这个蛋白质的别的产品。 总共97 ITCH产品已列进来了。
6720481N21Rik, 8030492O04Rik, A130065M08, AIF4, AIP4, C230047C07Rik, dJ468O1.1, NAPP1
列出全部抗体 基因 基因ID UniProt
ITCH 83737 Q96J02
ITCH 16396 Q8C863



最受欢迎的抗anti-ITCH (ITCH) 抗体


抗Human ITCH 抗体:

抗Mouse (Murine) ITCH 抗体:

抗Rat (Rattus) ITCH 抗体:

所有可销售的anti-ITCH 抗体


引用最多的anti-ITCH 抗体

  1. Human Polyclonal ITCH Primary Antibody for ELISA, WB - ABIN1533142 : Chen, Wen, Fukuda, Gavva, Hsu, Akama, Yang-Feng, Shen: Human ITCH is a coregulator of the hematopoietic transcription factor NF-E2. in Genomics 2001 (PubMed)
    Show all 2 references for 1533142

  2. Human Polyclonal ITCH Primary Antibody for IHC, ELISA - ABIN1532110 : Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: The DNA sequence and comparative analysis of human chromosome 20. ... in Nature 2002 (PubMed)
    Show all 2 references for 1532110

  3. Human Polyclonal ITCH Primary Antibody for ICC, IF - ABIN4327763 : Bozóky, Savchenko, Csermely, Korcsmáros, Dúl, Pontén, Székely, Klein: Novel signatures of cancer-associated fibroblasts. in International journal of cancer 2013 (PubMed)

  4. Human Polyclonal ITCH Primary Antibody for ELISA, WB - ABIN261096 : Di Marcotullio, Ferretti, Greco, De Smaele, Po, Sico, Alimandi, Giannini, Maroder, Screpanti, Gulino: Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. in Nature cell biology 2006 (PubMed)

  5. Human Monoclonal ITCH Primary Antibody for IF, WB - ABIN968414 : Perry, Hustad, Swing, OSullivan, Jenkins, Copeland: The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. in Nature genetics 1998 (PubMed)

  6. Mouse (Murine) Polyclonal ITCH Primary Antibody for WB - ABIN657549 : Lohr, Molleston, Strauss, Torres-Martinez, Sherman, Squires, Rider, Chikwava, Cummings, Morton, Puffenberger: Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease. in American journal of human genetics 2010 (PubMed)


Human Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) (ITCH) interaction partners

  1. Describe an autoinhibitory mechanism for ITCH ubiquitin ligase involving a linker-HECT domain interaction. This intramolecular interaction traps the HECT enzyme in its inactive state and can be relieved by linker phosphorylation.

  2. Data show that the E3 ubiquitin ligase (显示 MUL1 抗体) Itch forms a complex with tricellulin (显示 MARVELD2 抗体) and thereby enhances its ubiquitination.

  3. ASPP2 (显示 TP53BP2 抗体) suppresses invasion, peritoneal dissemination and TGF-beta1 (显示 TGFB1 抗体)-induced EMT (显示 ITK 抗体) by inhibiting Smad7 (显示 SMAD7 抗体) degradation mediated by ITCH in gastric cancer cells.

  4. WBP2 (显示 WBP2 抗体)/ITCH signaling functions to link the intricate Wnt (显示 WNT2 抗体) and Hippo signaling networks in breast cancer.

  5. The cellular ubiquitin ligase, Itch, is required for Kaposi's sarcoma herpesvirus RTA (显示 RBM9 抗体) induced degradation of vFLIP.

  6. Results indicate that TAX1BP1 (显示 TAX1BP1 抗体) functions as an adaptor molecule for Itch to target MAVS (显示 MAVS 抗体) during RNA virus infection and thus restrict virus-induced apoptosis.

  7. These data demonstrate that Itch, ubiquitin, and Alix (显示 PDCD6IP 抗体) control the BFRF1-mediated modulation of the nuclear envelope and human herpesvirus 4 maturation, uncovering novel regulatory mechanisms of nuclear egress of viral nucleocapsids.

  8. The authors demonstrate that the PPxY L domain motif of ebolavirus VP40 interacts specifically with the WW domain (显示 DRP2 抗体) of the host E3 ubiquitin ligase (显示 MUL1 抗体) ITCH.

  9. Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch.

  10. cir (显示 KCNJ5 抗体)-ITCH may play an inhibitory role in lung cancer progression by enhancing its parental gene, ITCH, expression

Mouse (Murine) Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) (ITCH) interaction partners

  1. this study identified a previously unknown role for Itch in regulating IL-17 (显示 IL17A 抗体)-mediated colonic inflammation and carcinogenesis

  2. Itch monoubiquitinates SMN (显示 STMN1 抗体) and monoubiquitination of SMN (显示 STMN1 抗体) plays an important role in regulating its cellular localization.

  3. ITCH targets TXNIP (显示 TXNIP 抗体) for ubiquitin-proteasome degradation in cardiomyocytes and ameliorates reactive oxygen species-induced cardiotoxicity through the thioredoxin (显示 TXN 抗体) system.

  4. CUL4B links two distinct spermatogenetic processes to a single E3 ligase, highlighting the significance of ubiquitin modification during spermatogenesis.

  5. Impaired ITCH results in heightened TNF (显示 TNF 抗体) signaling. ITCH-/- mouse's spontaneous lung inflammation and subsequent death can be delayed when TNF (显示 TNF 抗体) signaling is genetically deleted.

  6. ITCH modulates SIRT6 (显示 SIRT6 抗体) and SREBP2 (显示 SREBF2 抗体) to influence lipid metabolism and atherosclerosis in ApoE (显示 APOE 抗体) null mice

  7. In the absence of Ndfip1, the Nedd4 family member Itch can bind an E2 but cannot accept ubiquitin onto its catalytic cysteine.

  8. The E3 ubiquitin ligase (显示 MUL1 抗体) Itch inhibits p38alpha (显示 MAPK14 抗体) signaling and skin inflammation through the ubiquitylation of Tab1 (显示 TAB1 抗体).

  9. Ndfip1 (显示 NDFIP1 抗体) regulates itch ligase activity and airway inflammation via UbcH7 (显示 UBE2L3 抗体).

  10. The expression of Th2 cytokines by Treg cells was increased in the absence of Itch. Fate mapping revealed that a fraction of Treg cells lost Foxp3 (显示 FOXP3 抗体) expression independently of Itch.

ITCH 抗原简介

Antigen Summary

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with ITCH

  • itchy E3 ubiquitin protein ligase (ITCH) 抗体
  • itchy, E3 ubiquitin protein ligase (Itch) 抗体
  • 6720481N21Rik 抗体
  • 8030492O04Rik 抗体
  • A130065M08 抗体
  • AIF4 抗体
  • AIP4 抗体
  • C230047C07Rik 抗体
  • dJ468O1.1 抗体
  • NAPP1 抗体

Protein level used designations for ITCH

E3 ubiquitin-protein ligase Itchy homolog , NFE2-associated polypeptide 1 , atrophin-1 interacting protein 4 , dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4)) , itchy E3 ubiquitin protein ligase homolog , E3 ubiquitin-protein ligase Itchy

83737 Homo sapiens
16396 Mus musculus
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