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抗Human ITCH 抗体:
抗Mouse (Murine) ITCH 抗体:
抗Rat (Rattus) ITCH 抗体:
Human Monoclonal ITCH Primary Antibody for IF, WB - ABIN968415
Perry, Hustad, Swing, OSullivan, Jenkins, Copeland: The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. in Nature genetics 1998
Human Polyclonal ITCH Primary Antibody for ICC, IF - ABIN4327763
Bozóky, Savchenko, Csermely, Korcsmáros, Dúl, Pontén, Székely, Klein: Novel signatures of cancer-associated fibroblasts. in International journal of cancer 2013
Human Polyclonal ITCH Primary Antibody for ELISA, WB - ABIN261096
Di Marcotullio, Ferretti, Greco, De Smaele, Po, Sico, Alimandi, Giannini, Maroder, Screpanti, Gulino: Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. in Nature cell biology 2006
JunB (显示 JUNB 抗体) neddylation mediated by Itch promotes its ubiquitination-dependent degradation.
Describe an autoinhibitory mechanism for ITCH ubiquitin ligase involving a linker-HECT domain interaction. This intramolecular interaction traps the HECT enzyme in its inactive state and can be relieved by linker phosphorylation.
Data show that the E3 ubiquitin ligase (显示 MUL1 抗体) Itch forms a complex with tricellulin (显示 MARVELD2 抗体) and thereby enhances its ubiquitination.
ASPP2 (显示 TP53BP2 抗体) suppresses invasion, peritoneal dissemination and TGF-beta1 (显示 TGFB1 抗体)-induced EMT (显示 ITK 抗体) by inhibiting Smad7 (显示 SMAD7 抗体) degradation mediated by ITCH in gastric cancer cells.
WBP2 (显示 WBP2 抗体)/ITCH signaling functions to link the intricate Wnt (显示 WNT2 抗体) and Hippo signaling networks in breast cancer.
The cellular ubiquitin ligase, Itch, is required for Kaposi's sarcoma herpesvirus RTA (显示 RBM9 抗体) induced degradation of vFLIP.
Results indicate that TAX1BP1 (显示 TAX1BP1 抗体) functions as an adaptor molecule for Itch to target MAVS (显示 MAVS 抗体) during RNA virus infection and thus restrict virus-induced apoptosis.
These data demonstrate that Itch, ubiquitin, and Alix (显示 PDCD6IP 抗体) control the BFRF1-mediated modulation of the nuclear envelope and human herpesvirus 4 maturation, uncovering novel regulatory mechanisms of nuclear egress of viral nucleocapsids.
The authors demonstrate that the PPxY L domain motif of ebolavirus VP40 interacts specifically with the WW domain (显示 DRP2 抗体) of the host E3 ubiquitin ligase (显示 MUL1 抗体) ITCH.
Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch.
this study identified a previously unknown role for Itch in regulating IL-17 (显示 IL17A 抗体)-mediated colonic inflammation and carcinogenesis
Itch monoubiquitinates SMN (显示 STMN1 抗体) and monoubiquitination of SMN (显示 STMN1 抗体) plays an important role in regulating its cellular localization.
ITCH targets TXNIP (显示 TXNIP 抗体) for ubiquitin-proteasome degradation in cardiomyocytes and ameliorates reactive oxygen species-induced cardiotoxicity through the thioredoxin (显示 TXN 抗体) system.
CUL4B links two distinct spermatogenetic processes to a single E3 ligase, highlighting the significance of ubiquitin modification during spermatogenesis.
Impaired ITCH results in heightened TNF (显示 TNF 抗体) signaling. ITCH-/- mouse's spontaneous lung inflammation and subsequent death can be delayed when TNF (显示 TNF 抗体) signaling is genetically deleted.
ITCH modulates SIRT6 (显示 SIRT6 抗体) and SREBP2 (显示 SREBF2 抗体) to influence lipid metabolism and atherosclerosis in ApoE (显示 APOE 抗体) null mice
In the absence of Ndfip1, the Nedd4 family member Itch can bind an E2 but cannot accept ubiquitin onto its catalytic cysteine.
The E3 ubiquitin ligase (显示 MUL1 抗体) Itch inhibits p38alpha (显示 MAPK14 抗体) signaling and skin inflammation through the ubiquitylation of Tab1 (显示 TAB1 抗体).
Ndfip1 (显示 NDFIP1 抗体) regulates itch ligase activity and airway inflammation via UbcH7 (显示 UBE2L3 抗体).
The expression of Th2 cytokines by Treg cells was increased in the absence of Itch. Fate mapping revealed that a fraction of Treg cells lost Foxp3 (显示 FOXP3 抗体) expression independently of Itch.
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
E3 ubiquitin-protein ligase Itchy homolog
, NFE2-associated polypeptide 1
, atrophin-1 interacting protein 4
, dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4))
, itchy E3 ubiquitin protein ligase homolog
, E3 ubiquitin-protein ligase Itchy