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CD109 knockdown upregulated IL-8 (显示 IL8 ELISA试剂盒) expression through activation of TGF-beta (显示 TGFB1 ELISA试剂盒)/Akt (显示 AKT1 ELISA试剂盒)/NF-kappaB (显示 NFKB1 ELISA试剂盒) pathway in human umbilical vein endothelial cells
High expression of CD109 in brain tumor stem cells is involved in glioma progression.
The CD109 protein was up-regulated in hepatocellular carcinoma tissue compared with adjacent noncancerous tissue. CD109 shRNA knockdown delayed the G1-S phase transition, abrogated cell proliferation, and increased cell apoptosis. Furthermore, CD109 impaired TGF-beta (显示 TGFB1 ELISA试剂盒)/Smad (显示 SMAD1 ELISA试剂盒) signaling through control of p-smad2 (显示 SMAD2 ELISA试剂盒).
CD109 is a putative biomarker for identifying a high-risk group among DLBCL patients.
The most common HPA (显示 HPSE ELISA试剂盒) genotypes among Saudis were HPA-1 (显示 HPSE ELISA试剂盒) a + b- (75%), HPA-2 (显示 HPSE2 ELISA试剂盒) a + b- (62%), HPA-3 a + b- (51.5%), HPA (显示 HPSE ELISA试剂盒)-4 a + b- (99%), HPA-5 (显示 ITGA2 ELISA试剂盒) a + b- (76.5%), HPA (显示 HPSE ELISA试剂盒)-6 a + b- (100%) and HPA (显示 HPSE ELISA试剂盒)-15 a + b + (50%). The prevalent allele among the HPA (显示 HPSE ELISA试剂盒) systems was (a), except in the HPA (显示 HPSE ELISA试剂盒)-15 system where the (b) allele was found in 52% of the subjects.
Expression levels of CD109 was reduced significantly in psoriasis. Lower expression of CD109 and TGF-beta (显示 TGFB1 ELISA试剂盒) RI was highly correlated with higher expression of Smad7 (显示 SMAD7 ELISA试剂盒) and Ki67 (显示 MKI67 ELISA试剂盒), suggesting that CD109 may induce the pathogenesis of psoriasis through Smad7 (显示 SMAD7 ELISA试剂盒)-mediated degradation of TGF-beta (显示 TGFB1 ELISA试剂盒) RI.
sCD109 can bind TGF-beta (显示 TGFB1 ELISA试剂盒), inhibit TGF-beta (显示 TGFB1 ELISA试剂盒) binding to its receptors and decrease TGF-beta (显示 TGFB1 ELISA试剂盒) signalling and TGF-beta (显示 TGFB1 ELISA试剂盒)-induced cellular responses.
These findings indicate that CD109 is an exosomal protein and that the C-terminal region of CD109 is required for its presence in the exosome.
CD109 may be a potential pathology marker for gallbladder squamous cell/adenosquamous carcinomas.
CD109 is specifically expressed in endothelial cells of cutaneous cavernous haemangioma.
platelet and endothelial GARP (显示 LRRC32 ELISA试剂盒) are not important in hemostasis and thrombosis in mice
Small-scale in vivo screening identified several genes, including Cd109, that encode novel pro-metastatic factors. We uncovered signaling mediated by Janus kinases (Jaks) and the transcription factor Stat3 (显示 STAT3 ELISA试剂盒) as a critical, pharmacologically targetable effector of CD109-driven lung cancer metastasis
CD109 differentially regulates TGF-beta (显示 TGFB1 ELISA试剂盒)-induced ALK1 (显示 ACVRL1 ELISA试剂盒)-Smad1 (显示 SMAD1 ELISA试剂盒)/5 versus ALK5 (显示 TGFBR1 ELISA试剂盒)-Smad2 (显示 SMAD2 ELISA试剂盒)/3 pathways, leading to decreased extracellular matrix production in the skin; epidermal CD109 expression regulates dermal function through a paracrine mechanism
the GARP (显示 LRRC32 ELISA试剂盒)/LTGF-beta1 complex on Treg cells is a major source of TGF-beta1 (显示 TGFB1 ELISA试剂盒) needed for induction of pTreg cells during the process of oral tolerance.
GP96 (显示 HSP90B1 ELISA试剂盒) serves as an essential chaperone for the cell-surface protein (显示 CD28 ELISA试剂盒) glycoprotein A repetitions predominant (GARP (显示 LRRC32 ELISA试剂盒)), which is a docking receptor for latent membrane-associated TGF-beta (显示 TGFB1 ELISA试剂盒) (mLTGF-beta).
CD109 decreases extracellular matrix production and fibrotic responses during hypoxic wound healing
CD109 is present in serum as a soluble form, and suggest its potential as a novel tumor marker in patients with cancers that express CD109.
CD109 might be an important regulator of osteoclastogenesis.
findings demonstrate that CD109 overexpression in the epidermis reduces inflammation and granulation tissue area and improves collagen organization in vivo.
This gene encodes a member of the alpha2-macroglobulin/complement superfamily. The encoded GPI-linked glycoprotein is found on the cell surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signaling of transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene.
150 kDa TGF-beta-1-binding protein
, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7
, CD109 antigen
, Gov platelet alloantigens
, activated T-cell marker CD109
, platelet-specific Gov antigen
, CD109 molecule
, CD109 antigen-like
, GPI-anchored alpha 2 macroglobulin-related protein
, GPI-anchored alpha-2 macroglobulin-related protein