NEW: 请通过本地经销商订购 4A Biotech Co.,Ltd.


ABIN1001635 产品详细信息, 供应商: Log in to see
大肠杆菌(E. Coli)
Log in to see
Supplier Product No.
Log in to see

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

特异性 Voltage-gated channel (Kv1.3) blocker. rBmKTX blocks Kv1.3 channels with IC50 of 019 nM.
产品特性 Source: Mesobuthus Martensii (Buthus martensii).
Molecular formula: C169H274N52O47S7.
Disulfide bonds between Cys7-Cys27, Cys13-Cys32, and Cys17-Cys34.
纯度 > 98 %
背景 BmKTX inhibits Kv1.3 channels heterologously expressed in HEK-293 cells. Kv1.3 channel currents, before and after application of 100pM BmKTX. Kv1.3 channel currents were elicited by depolarizing the voltage steps of 200 ms from the holding potential -80 mV to +50 mV.
分子量 3962
应用备注 0.1-1nM

K+ channel toxin -KTx 3.6

限制 仅限研究用
状态 Lyophilized
溶解方式 Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 1.262ml will provide a stock solution of 10 M.
注意事项 Soluble in Water.
 image for rBmKTX (ABIN1001635) Kv1.3 channel currents, before and after application of 100pM BmKTX. Kv1.3 channel cu...
有引用在: Renisio, Romi-Lebrun, Blanc, Bornet, Nakajima, Darbon: "Solution structure of BmKTX, a K+ blocker toxin from the Chinese scorpion Buthus Martensi." in: Proteins, Vol. 38, Issue 1, pp. 70-8, 2000 (PubMed).

Dai, Wu, Gu, Lan, Ling, Chi: "Genomic organization of three novel toxins from the scorpion Buthus martensi Karsch that are active on potassium channels." in: The Biochemical journal, Vol. 346 Pt 3, pp. 805-9, 2000 (PubMed).

Romi-Lebrun, Lebrun, Martin-Eauclaire, Ishiguro, Escoubas, Wu, Hisada, Pongs, Nakajima: "Purification, characterization, and synthesis of three novel toxins from the Chinese scorpion Buthus martensi, which act on K+ channels." in: Biochemistry, Vol. 36, Issue 44, pp. 13473-82, 1997 (PubMed).