ADWX-1

ABIN1001633 产品详细信息, 供应商: Log in to see
适用
Scorpion
宿主
大肠杆菌(E. Coli)
选项
Supplier
Log in to see
Supplier Product No.
Log in to see
序列 VGINVKCKHS RQCLKPCKDA GMRFGKCTNG KCHCTPK.
特异性 Voltage-gated channel (Kv1.3 and Kv1.1) blocker. ADWX-1 blocks Kv1.3 channels with IC50 of 019 nM, and inhibits Kv1.1 channels with IC50 of 0.65nM.
产品特性 Source: Mesobuthus Martensii (Buthus martensii).
Molecular formula: C169H281N57O46S7.
Disulfide bonds between Cys7-Cys27, Cys13-Cys32, and Cys17-Cys34.
纯度 > 98 %
背景 ADWX-1 inhibits Kv1.3 channels heterologously expressed in HEK-293 cells. Kv1.3 channel currentsbefore and after application of 10pM ADWX-1. Kv1.3 channel currents were elicited by depolarizing the voltage steps of 200 ms from the holding potential -80 mV to +50 mV.
分子量 4072
应用备注 019-0.65nM
限制 仅限研究用
状态 Lyophilized
溶解方式 Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 1.228ml will provide a stock solution of 10M.
注意事项 Soluble in Water.
厂商提供的图像
 image for ADWX-1 (ABIN1001633) Kv1.3 channel currents, before and after application of 10pM ADWX-1. Kv1.3 channel cu...
有引用在: Yin, Jiang, Yi, Han, Yang, Liu, Liu, Cao, Wu, Li: "Different residues in channel turret determining the selectivity of ADWX-1 inhibitor peptide between Kv1.1 and Kv1.3 channels." in: Journal of proteome research, Vol. 7, Issue 11, pp. 4890-7, 2008 (PubMed).

Han, Yi, Yin, Chen, Liu, Cao, Wu, Li: "Structural basis of a potent peptide inhibitor designed for Kv1.3 channel, a therapeutic target of autoimmune disease." in: The Journal of biological chemistry, Vol. 283, Issue 27, pp. 19058-65, 2008 (PubMed).